Ferroptosis in Adipose Tissue: A Double-Edged Sword Between Obesity Therapy and Stem Cell Risk

Keywords

adipose tissue / ferroptosis / obesity treatment / stem cells

References

[1] X. Wang, Q. Wu, M. Zhong, et al., “Adipocyte-Derived Ferroptotic Signaling Mitigates Obesity,” Cell Metabolism 37, no. 3 (2025): 673–691.e7.

[2] D. Tang, X. Chen, R. Kang, and G. Kroemer, “Ferroptosis: Molecular Mechanisms and Health Implications,” Cell Research 31, no. 2 (2021): 107–125.

[3] Y. Qin, G. Ge, P. Yang, et al., “An Update on Adipose-Derived Stem Cells for Regenerative Medicine: Where Challenge Meets Opportunity,” Advanced Science 10, no. 20 (2023): e2207334.

[4] H. Nahmgoong, Y. G. Jeon, E. S. Park, et al., “Distinct Properties of Adipose Stem Cell Subpopulations Determine Fat Depot-Specific Characteristics,” Cell Metabolism 34, no. 3 (2022): 458–472.e6.

[5] M. G. Valorani, E. Montelatici, A. Germani, et al., “Pre-Culturing Human Adipose Tissue Mesenchymal Stem Cells Under Hypoxia Increases Their Adipogenic and Osteogenic Differentiation Potentials,” Cell Proliferation 45, no. 3 (2012): 225–238.

RIGHTS & PERMISSIONS

2025 The Author(s). MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.