Circulating Interleukin-6 Predicts Adverse Outcomes in Asians with Hypertrophic Cardiomyopathy

Thu-Thao Le; Shiqi Lim; Chengxi Yang; Jennifer Ann Bryant; Yiying Han; Soon Kieng Phua; Tar-Choon Aw; Stuart Alexander Cook; Calvin Woon-Loong Chin

doi:10.1002/mco2.70463

MedComm ›› 2025, Vol. 6 ›› Issue (12) :e70463 DOI: 10.1002/mco2.70463

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Circulating Interleukin-6 Predicts Adverse Outcomes in Asians with Hypertrophic Cardiomyopathy

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Thu-Thao Le, Shiqi Lim, Chengxi Yang, Jennifer Ann Bryant, Yiying Han, Soon Kieng Phua, Tar-Choon Aw, Stuart Alexander Cook, Calvin Woon-Loong Chin. Circulating Interleukin-6 Predicts Adverse Outcomes in Asians with Hypertrophic Cardiomyopathy. MedComm, 2025, 6(12): e70463 DOI:10.1002/mco2.70463

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References

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[1]	S. Neubauer, P. Kolm, C. Y. Ho, et al., “Distinct Subgroups in Hypertrophic Cardiomyopathy in the NHLBI HCM Registry,” Journal of the American College of Cardiology 74, no. 19 (2019): 2333–2345. Kuusisto J, Kärjä V, Sipola P, et al. Heart. 2012;98(13):1007–1013.

[2]	M. Jansen, S. Algul, L. P. Bosman, et al., “Blood-based Biomarkers for the Prediction of Hypertrophic Cardiomyopathy Prognosis: A Systematic Review and Meta-analysis,” ESC Heart Failure 9, no. 5 (2022): 3418–3434.

[3]	R. Lillo, F. Graziani, F. Franceschi, et al., “Inflammation Across the Spectrum of Hypertrophic Cardiac Phenotypes,” Heart Failure Reviews 28, no. 5 (2023): 1065–1075.

[4]

S. R. Ommen, S. Mital, M. A. Burke, et al., “2020 AHA/ACC Guideline for the Diagnosis and Treatment of Patients with Hypertrophic Cardiomyopathy: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines,” Journal of the American College of Cardiology 76, no. 25 (2020): e159–e240.

[5]	G. C. Melendez, J. L. McLarty, S. P. Levick, Y. Du, J. S. Janicki, and G. L. Brower, “Interleukin 6 Mediates Myocardial Fibrosis, Concentric Hypertrophy, and Diastolic Dysfunction in Rats,” Hypertension 56, no. 2 (2010): 225–231.

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