Ultrahigh Dose Rate Irradiation Regulates Mitochondrial DNA-induced Interferon-β Secretion via Cytochrome c Leakage

Jianfeng Lv; Jianhan Sun; Yunbin Luo; Juntao Liu; Di Wu; Yiyu Fang; Gerard Mourou; Senlin Huang; Gen Yang; Xueqing Yan

doi:10.1002/mco2.70457

MedComm ›› 2025, Vol. 6 ›› Issue (11) : e70457 DOI: 10.1002/mco2.70457

LETTER

Ultrahigh Dose Rate Irradiation Regulates Mitochondrial DNA-induced Interferon-β Secretion via Cytochrome c Leakage

Author information +

History +

PDF

Cite this article

Download citation ▾

Jianfeng Lv, Jianhan Sun, Yunbin Luo, Juntao Liu, Di Wu, Yiyu Fang, Gerard Mourou, Senlin Huang, Gen Yang, Xueqing Yan. Ultrahigh Dose Rate Irradiation Regulates Mitochondrial DNA-induced Interferon-β Secretion via Cytochrome c Leakage. MedComm, 2025, 6(11): e70457 DOI:10.1002/mco2.70457

登录浏览全文

4963

注册一个新账户忘记密码

References

Publishing order | Descend order by publishing year | Descend order by cited within

[1]	V. Favaudon, L. Caplier, V. Monceau, et al., “Ultrahigh Dose-rate FLASH Irradiation Increases the Differential Response Between Normal and Tumor Tissue in Mice,” Science Translational Medicine 6, no. 245 (2014): 245ra93.

[2]	Y. Ma, W. Zhang, Z. Zhao, et al., “Current Views on Mechanisms of the FLASH Effect in Cancer Radiotherapy,” National Science Review (2024): nwae350.

[3]	C. H. Han, Z. D. Liu, Y. J. Zhang, et al., “Tumor Cells Suppress Radiation-induced Immunity by Hijacking Caspase 9 Signaling,” Nature Immunology 21, no. 5 (2020): 546-554.

[4]	A. Rongvaux, R. Jackson, C. C. D. Harman, et al., “Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA,” Cell 159, no. 7 (2014): 1563-1577.

[5]	X. L. Shi, Y. W. Yang, W. Zhang, et al., “FLASH X-ray Spares Intestinal Crypts From Pyroptosis Initiated by cGAS-STING Activation Upon Radioimmunotherapy,” Proceedings of the National Academy of Sciences of the United States of America 119, no. 43 (2022): e2208506119.

RIGHTS & PERMISSIONS

2025 The Author(s). MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.