D1 Receptor Agonist Ameliorates Synaptic and Behavioral Deficits in a Shank3-Deficient Mouse Model of Autism

Jun-Sik Kim , Sukmin Han , Mihyeon An , Jinsu Park , Yeongyeong Lee , Jeein Lim , Sung Hyun Kim , Dong-Gyu Jo

MedComm ›› 2025, Vol. 6 ›› Issue (11) : e70428

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MedComm ›› 2025, Vol. 6 ›› Issue (11) : e70428 DOI: 10.1002/mco2.70428
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D1 Receptor Agonist Ameliorates Synaptic and Behavioral Deficits in a Shank3-Deficient Mouse Model of Autism

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Jun-Sik Kim, Sukmin Han, Mihyeon An, Jinsu Park, Yeongyeong Lee, Jeein Lim, Sung Hyun Kim, Dong-Gyu Jo. D1 Receptor Agonist Ameliorates Synaptic and Behavioral Deficits in a Shank3-Deficient Mouse Model of Autism. MedComm, 2025, 6(11): e70428 DOI:10.1002/mco2.70428

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References

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J. Peça, C. Feliciano, J. T. Ting, et al., “Shank3 Mutant Mice Display Autistic-Like Behaviours and Striatal Dysfunction,” Nature 472, no. 7344 (2011): 437-442.

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P. Kosillo and H. S. Bateup, “Dopaminergic Dysregulation in Syndromic Autism Spectrum Disorders: Insights from Genetic Mouse Models,” Front Neural Circuits 15 (2021): 700968.

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Y. Zhuang, B. Krumm, H. Zhang, et al., “Mechanism of Dopamine Binding and Allosteric Modulation of the Human D1 Dopamine Receptor,” Cell Research 31, no. 5 (2021): 593-596.

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S. Tzanoulinou, S. Musardo, A. Contestabile, et al., “Inhibition of Trpv4 Rescues Circuit and Social Deficits Unmasked by Acute Inflammatory Response in a Shank3 Mouse Model of Autism,” Molecular Psychiatry 27, no. 4 (2022): 2080-2094.

[5]

A. L. Bey, X. Wang, H. Yan, et al., “Brain Region-Specific Disruption of Shank3 in Mice Reveals a Dissociation for Cortical and Striatal Circuits in Autism-Related Behaviors,” Translational Psychiatry 8, no. 1 (2018): 94.

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2025 The Author(s). MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.

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