Insulin-Like Growth Factor 2 mRNA Binding Protein 2 Promotes HBV-Associated Hepatocellular Carcinoma Progression by Enhancing Heme Oxygenase 1 Stability in an M6A-dependent Manner

Yan Zhao; Yan Cui; Hongxiu Qiao; Sandra Chiu; Xia Chuai

doi:10.1002/mco2.70371

MedComm ›› 2025, Vol. 6 ›› Issue (9) : e70371 DOI: 10.1002/mco2.70371

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Insulin-Like Growth Factor 2 mRNA Binding Protein 2 Promotes HBV-Associated Hepatocellular Carcinoma Progression by Enhancing Heme Oxygenase 1 Stability in an M⁶A-dependent Manner

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Yan Zhao, Yan Cui, Hongxiu Qiao, Sandra Chiu, Xia Chuai. Insulin-Like Growth Factor 2 mRNA Binding Protein 2 Promotes HBV-Associated Hepatocellular Carcinoma Progression by Enhancing Heme Oxygenase 1 Stability in an M⁶A-dependent Manner. MedComm, 2025, 6(9): e70371 DOI:10.1002/mco2.70371

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References

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[3]	C. Y. Sun, D. Cao, B. B. Du, C. W. Chen, and D. Liu, “The Role of Insulin-Like Growth Factor 2 mRNA-Binding Proteins (IGF2BPs) as M(6)A Readers in Cancer,” International Journal of Biology Sciences 18, no. 7 (2022): 2744-2758.

[4]	F. Yang, L. Ma, Y. Yang, et al., “Contribution of Hepatitis B Virus Infection to the Aggressiveness of Primary Liver Cancer: A Clinical Epidemiological Study in Eastern China,” Frontiers in Oncology 9 (2019): 370.

[5]	Z. Xie, Y. Zhou, M. Lin, and C. Huang, “Binding of Berberine to PEBP1 Synergizes With Sorafenib to Induce the Ferroptosis of Hepatic Stellate Cells,” Amino Acids 55, no. 12 (2023): 1867-1878.

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