Hepatitis B Virus Assembly: Cryo-Electron Microscopy Reveals Structure of the Surface Antigen

Guobao Li; Jiaxin Cui; Jifeng Nie

doi:10.1002/mco2.70348

MedComm ›› 2025, Vol. 6 ›› Issue (9) : e70348 DOI: 10.1002/mco2.70348

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Hepatitis B Virus Assembly: Cryo-Electron Microscopy Reveals Structure of the Surface Antigen

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Guobao Li, Jiaxin Cui, Jifeng Nie. Hepatitis B Virus Assembly: Cryo-Electron Microscopy Reveals Structure of the Surface Antigen. MedComm, 2025, 6(9): e70348 DOI:10.1002/mco2.70348

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References

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[1]	Q. Wang, T. Wang, L. Cao, et al., “Inherent Symmetry and Flexibility in Hepatitis B Virus Subviral Particles,” Science 385, no. 6714 (2024): 1217-1224.

[2]	H. Liu, X. Hong, J. Xi, S. Menne, J. Hu, and J. C. Wang, “Cryo-EM Structures of Human Hepatitis B and Woodchuck Hepatitis Virus Small Spherical Subviral Particles,” Science Advances 8, no. 31 (2022): eabo4184.

[3]	X. He, Y. Kang, W. Tao, J. Xu, X. Liu, and L. Chen, “Structure of Small HBV Surface Antigen Reveals Mechanism of Dimer Formation,” Cell Discovery 11, no. 1 (2025): 6.

[4]	B. Venkatakrishnan and A. Zlotnick, “The Structural Biology of Hepatitis B Virus: Form and Function,” Annual Review of Virology 3, no. 1 (2016): 429-451.

[5]	S. Seitz, J. Habjanic, A. K. Schutz, and R. Bartenschlager, “The Hepatitis B Virus Envelope Proteins: Molecular Gymnastics Throughout the Viral Life Cycle,” Annual Review of Virology 7, no. 1 (2020): 263-288.

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