Dysfunctional Lipid-Induced Secretion of Glucagon-Like Peptide-2(GLP-2), but Not of Incretins Glucagon-Like Peptide-1(GLP-1)/Glucose-Dependent Insulinotropic Polypeptide(GIP), Promotes Metabolic Dysfunction–Associated Steatotic Liver Disease (MASLD) Onset and Progression Through Gut Barrier Disruption and Endotoxemia

Giovanni Musso , Silvia Pinach , Alberto Mella , Franco De Michieli , Anna Calabrese , Deborah Trifiro , Giovanna Petrangolini , Maurizio Cassader , Filippo Mariano , Roberto Gambino

MedComm ›› 2026, Vol. 7 ›› Issue (4) : e70323

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MedComm ›› 2026, Vol. 7 ›› Issue (4) :e70323 DOI: 10.1002/mco2.70323
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Dysfunctional Lipid-Induced Secretion of Glucagon-Like Peptide-2(GLP-2), but Not of Incretins Glucagon-Like Peptide-1(GLP-1)/Glucose-Dependent Insulinotropic Polypeptide(GIP), Promotes Metabolic Dysfunction–Associated Steatotic Liver Disease (MASLD) Onset and Progression Through Gut Barrier Disruption and Endotoxemia
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endotoxemia / intestinal barrier / LPS / NF-kB / postprandial / steatohepatitis

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Giovanni Musso, Silvia Pinach, Alberto Mella, Franco De Michieli, Anna Calabrese, Deborah Trifiro, Giovanna Petrangolini, Maurizio Cassader, Filippo Mariano, Roberto Gambino. Dysfunctional Lipid-Induced Secretion of Glucagon-Like Peptide-2(GLP-2), but Not of Incretins Glucagon-Like Peptide-1(GLP-1)/Glucose-Dependent Insulinotropic Polypeptide(GIP), Promotes Metabolic Dysfunction–Associated Steatotic Liver Disease (MASLD) Onset and Progression Through Gut Barrier Disruption and Endotoxemia. MedComm, 2026, 7 (4) : e70323 DOI:10.1002/mco2.70323

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