Metabolic and Epigenetic Control of CD8+ T Cell Exhaustion: The Acetate-to-Citrate Switch

Xiaoyi Lei; Wei Zhang; Dunfang Zhang

doi:10.1002/mco2.70307

MedComm ›› 2025, Vol. 6 ›› Issue (8) : e70307 DOI: 10.1002/mco2.70307

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Metabolic and Epigenetic Control of CD8⁺ T Cell Exhaustion: The Acetate-to-Citrate Switch

Xiaoyi Lei ¹^,²
, Wei Zhang ¹^,²
, Dunfang Zhang ¹^,²

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Xiaoyi Lei, Wei Zhang, Dunfang Zhang. Metabolic and Epigenetic Control of CD8⁺ T Cell Exhaustion: The Acetate-to-Citrate Switch. MedComm, 2025, 6(8): e70307 DOI:10.1002/mco2.70307

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References

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[2]	E. J. Wherry and M. Kurachi, “Molecular and Cellular Insights Into T Cell Exhaustion,” Nature Reviews Immunology 15, no. 8 (2015): 486-499.

[3]	A. C. Scott, F. Dundar, P. Zumbo, et al., “TOX Is a Critical Regulator of Tumour-specific T Cell Differentiation,” Nature 571, no. 7764 (2019): 270-274.

[4]	H. Wu, X. Zhao, S. M. Hochrein, et al., “Mitochondrial Dysfunction Promotes the Transition of Precursor to Terminally Exhausted T Cells Through HIF-1alpha-mediated Glycolytic Reprogramming,” Nature Communications 14, no. 1 (2023): 6858.

[5]	L. Li, T. Xiang, J. Guo, et al., “Inhibition of ACSS2-mediated Histone Crotonylation Alleviates Kidney Fibrosis via IL-1beta-dependent Macrophage Activation and Tubular Cell Senescence,” Nature Communications 15, no. 1 (2024): 3200.

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