SARS-CoV-2 Spike S2 Refolding: Structural Insights and Inhibition Strategies Against Emerging Variants

Chen Xu; Wen Xie; Xinghua Long

doi:10.1002/mco2.70305

MedComm ›› 2025, Vol. 6 ›› Issue (8) : e70305 DOI: 10.1002/mco2.70305

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SARS-CoV-2 Spike S2 Refolding: Structural Insights and Inhibition Strategies Against Emerging Variants

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Chen Xu, Wen Xie, Xinghua Long. SARS-CoV-2 Spike S2 Refolding: Structural Insights and Inhibition Strategies Against Emerging Variants. MedComm, 2025, 6(8): e70305 DOI:10.1002/mco2.70305

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References

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[2]	P. Zhou, X. L. Yang, X. G. Wang, et al., “A Pneumonia Outbreak Associated With a New Coronavirus of Probable Bat Origin,” Nature 579, no. 7798 (2020): 270-273.

[3]	C. O. Barnes, C. A. Jette, M. E. Abernathy, et al., “SARS-CoV-2 Neutralizing Antibody Structures Inform Therapeutic Strategies,” Nature 588, no. 7839 (2020): 682-687.

[4]	P. Shah, G. A. Canziani, E. P. Carter, and I. Chaiken, “The Case for S2: The Potential Benefits of the S2 Subunit of the SARS-CoV-2 Spike Protein as an Immunogen in Fighting the COVID-19 Pandemic,” Frontiers in Immunology 12 (2021): 637651.

[5]	P. Zhou, G. Song, H. Liu, et al., “Broadly Neutralizing Anti-S2 Antibodies Protect Against all Three Human Betacoronaviruses That Cause Deadly Disease,” Immunity 56, no. 3 (2023): 669-686.

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