DLGAP5 mutations Disrupt Normal Chromosome Segregation and Spindle Formation of human Oocyte Meiosis and Lead to Female Infertility

Meng Wang , Zhou Li , Juepu Zhou , Rui Long , Qingsong Xi , Hong Gao , Youzhu Li , Lei Jin , Lixia Zhu

MedComm ›› 2025, Vol. 6 ›› Issue (6) : e70224

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MedComm ›› 2025, Vol. 6 ›› Issue (6) :e70224 DOI: 10.1002/mco2.70224
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DLGAP5 mutations Disrupt Normal Chromosome Segregation and Spindle Formation of human Oocyte Meiosis and Lead to Female Infertility

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Meng Wang, Zhou Li, Juepu Zhou, Rui Long, Qingsong Xi, Hong Gao, Youzhu Li, Lei Jin, Lixia Zhu. DLGAP5 mutations Disrupt Normal Chromosome Segregation and Spindle Formation of human Oocyte Meiosis and Lead to Female Infertility. MedComm, 2025, 6(6): e70224 DOI:10.1002/mco2.70224

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References

[1]

G. M. Chambers, S. Dyer, F. Zegers-Hochschild, et al., “International Committee for Monitoring Assisted Reproductive Technologies World Report: Assisted Reproductive Technology, 2014,” Human Reproduction (Oxford, England) 36, no. 11 (2021): 2921-2934.

[2]

W. Wang, Q. Sang, and L. Wang, “Genetic Factors of Oocyte Maturation Arrest: An Important Cause for Recurrent IVF/ICSI Failures,” Journal of Assisted Reproduction and Genetics 41, no. 8 (2024): 1951-1953.

[3]

Q. Sang, P. F. Ray, and L. Wang, “Understanding the Genetics of human Infertility,” Science (New York, NY) 380, no. 6641 (2023): 158-163.

[4]

A. P. Tsou, C. W. Yang, C. Y. Huang, et al., “Identification of a Novel Cell Cycle Regulated Gene, HURP, Overexpressed in human Hepatocellular Carcinoma,” Oncogene 22, no. 2 (2003): 298-307.

[5]

A. Saju, P. P. Chen, T. H. Weng, et al., “HURP Binding to the Vinca Domain of β-tubulin Accounts for Cancer Drug Resistance,” Nature Communications 15, no. 1 (2024): 8844.

[6]

J. Wong and G. Fang, “HURP Controls Spindle Dynamics to Promote Proper Interkinetochore Tension and Efficient Kinetochore Capture,” The Journal of Cell Biology 173, no. 6 (2006): 879-891.

[7]

M. D. Koffa, C. M. Casanova, R. Santarella, T. Köcher, M. Wilm, and I. W. Mattaj, “HURP Is Part of a Ran-Dependent Complex Involved in Spindle Formation,” Current Biology: CB 16, no. 8 (2006): 743-754.

[8]

V. A. Valdez, M. Ma, B. Gouveia, R. Zhang, and S. Petry, “HURP Facilitates Spindle Assembly by Stabilizing Microtubules and Working Synergistically With TPX2,” Nature Communications 15, no. 1 (2024): 9689.

[9]

C. Y. Tsai, C. K. Chou, C. W. Yang, et al., “Hurp Deficiency in Mice Leads to Female Infertility Caused by an Implantation Defect,” The Journal of Biological Chemistry 283, no. 39 (2008): 26302-26306.

[10]

M. Breuer, A. Kolano, M. Kwon, et al., “HURP Permits MTOC Sorting for Robust Meiotic Spindle Bipolarity, Similar to Extra Centrosome Clustering in Cancer Cells,” The Journal of Cell Biology 191, no. 7 (2010): 1251-1260.

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2025 The Author(s). MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.

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