Midnolin Ubiquitination is Required for its Proteasome-Mediated Degradation

Jiang He; Tangmin Lai; Yuzu Zhao; Haonan Yang; Zheng Lei; Liu Zhou; Nan Li; Yu He; Wei Zhou; YongZhong Wu

doi:10.1002/mco2.70189

MedComm ›› 2025, Vol. 6 ›› Issue (5) : e70189 DOI: 10.1002/mco2.70189

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Midnolin Ubiquitination is Required for its Proteasome-Mediated Degradation

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Jiang He, Tangmin Lai, Yuzu Zhao, Haonan Yang, Zheng Lei, Liu Zhou, Nan Li, Yu He, Wei Zhou, YongZhong Wu. Midnolin Ubiquitination is Required for its Proteasome-Mediated Degradation. MedComm, 2025, 6(5): e70189 DOI:10.1002/mco2.70189

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References

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[1]	X. Gu, C. Nardone, N. Kamitaki, A. Mao, S. J. Elledge, and M. E. Greenberg, “The Midnolin-Proteasome Pathway Catches Proteins for Ubiquitination-independent Degradation,” Science 381, no. 6660 (2023): eadh5021.

[2]	Y. Makaros, A. Raiff, R. T. Timms, et al., “Ubiquitin-Independent Proteasomal Degradation Driven by C-Degron Pathways,” Molecular Cell 83, no. 11 (2023): 1921-1935. e7.

[3]	X. Yan, X. Yuan, J. Lv, et al., “Molecular Basis of SAP05-mediated Ubiquitin-Independent Proteasomal Degradation of Transcription Factors,” Nature Communications 15, no. 1 (2024): 1170.

[4]	W. Huang, A. M. MacLean, A. Sugio, et al., “Parasitic Modulation of Host Development by Ubiquitin-Independent Protein Degradation,” Cell 184, no. 20 (2021): 5201-5214. e12.

[5]	P. Tsvetkov, N. Reuven, and Y. Shaul, “Ubiquitin-Independent p53 Proteasomal Degradation,” Cell Death & Differentiation 17, no. 1 (2010): 103-108.

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