Cryo-EM Structures Reveal Key Mechanisms of Noradrenaline Transporter

Peng Su; Mao Li; Fangfang Zhou

doi:10.1002/mco2.70188

MedComm ›› 2025, Vol. 6 ›› Issue (5) : e70188 DOI: 10.1002/mco2.70188

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Cryo-EM Structures Reveal Key Mechanisms of Noradrenaline Transporter

Peng Su ¹^,²
, Mao Li ¹
, Fangfang Zhou ¹^,³

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Peng Su, Mao Li, Fangfang Zhou. Cryo-EM Structures Reveal Key Mechanisms of Noradrenaline Transporter. MedComm, 2025, 6(5): e70188 DOI:10.1002/mco2.70188

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References

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[1]	T. Hu, Z. Yu, J. Zhao, et al., “Transport and Inhibition Mechanisms of the Human Noradrenaline Transporter,” Nature 632, no. 8026 (2024): 930-937.

[2]	J. A. Ross and E. J. Van Bockstaele, “The Locus Coeruleus-Norepinephrine System in Stress and Arousal: Unraveling Historical, Current, and Future Perspectives,” Frontiers in Psychiatry 11 (2020): 601519.

[3]	J. Tan, Y. Xiao, F. Kong, et al., “Molecular Basis of Human Noradrenaline Transporter Reuptake and Inhibition,” Nature 632, no. 8026 (2024): 921-929.

[4]	W. Ji, A. Miao, K. Liang, et al., “Substrate Binding and Inhibition Mechanism of Norepinephrine Transporter,” Nature 633, no. 8029 (2024): 473-479.

[5]	H. Zhang, Y. L. Yin, A. Dai, et al., “Dimerization and Antidepressant Recognition at Noradrenaline Transporter,” Nature 630, no. 8015 (2024): 247-254.

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