Broad-Spectrum Antiviral Activity of the Orally Bioavailable Antiviral ATV014 Against Multiple Coronaviruses

Sidi Yang; Kun Li; Qifan Zhou; Xumu Zhang; Deyin Guo

doi:10.1002/mco2.70186

MedComm ›› 2025, Vol. 6 ›› Issue (5) : e70186 DOI: 10.1002/mco2.70186

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Broad-Spectrum Antiviral Activity of the Orally Bioavailable Antiviral ATV014 Against Multiple Coronaviruses

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Sidi Yang, Kun Li, Qifan Zhou, Xumu Zhang, Deyin Guo. Broad-Spectrum Antiviral Activity of the Orally Bioavailable Antiviral ATV014 Against Multiple Coronaviruses. MedComm, 2025, 6(5): e70186 DOI:10.1002/mco2.70186

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References

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[1]	Q. Zhou, S. Yang, L. Cao, et al., “Preclinical Characterization and Anti-SARS-CoV-2 Efficacy of ATV014: An Oral Cyclohexanecarboxylate Prodrug of 1ʹ-CN-4-aza-7,9-Dideazaadenosine C-Nucleoside,” Signal Transduction and Targeted Therapy 8, no. 1 (2023): 27.

[2]	Y. Xie, W. Yin, Y. Zhang, et al., “Design and Development of an Oral Remdesivir Derivative VV116 Against SARS-CoV-2,” Cell Research 31, no. 11 (2021): 1212-1214.

[3]	L. Cao, Y. Li, S. Yang, et al., “The Adenosine Analog Prodrug ATV006 Is Orally Bioavailable and Has Preclinical Efficacy Against Parental SARS-CoV-2 and Variants,” Science Translational Medicine 14, no. 661 (2022): eabm7621.

[4]	D. R. Martinez, F. R. Moreira, N. J. Catanzaro, et al., “The Oral Nucleoside Prodrug GS-5245 Is Efficacious Against SARS-CoV-2 and Other Endemic, Epidemic, and Enzootic Coronaviruses,” Science Translational Medicine 16, no. 748 (2024): eadj4504.

[5]	J. J. Malin, I. Suarez, V. Priesner, G. Fatkenheuer, and J. Rybniker, “Remdesivir Against COVID-19 and Other Viral Diseases,” Clinical Microbiology Reviews 34, no. 1 (2020): e00162-20.

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