Single-Cell Transcriptomics Revealed E-Cigarettes-Induced Vascular Remodeling by Enhancing Tcf21 Expression

Ruiyang Ding , Xiaoke Ren , Qinglin Sun , Shiqian liu , Linyuan Huang , Zhiwei Sun , Junchao Duan

MedComm ›› 2025, Vol. 6 ›› Issue (5) : e70183

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MedComm ›› 2025, Vol. 6 ›› Issue (5) : e70183 DOI: 10.1002/mco2.70183
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Single-Cell Transcriptomics Revealed E-Cigarettes-Induced Vascular Remodeling by Enhancing Tcf21 Expression

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electronic cigarette / single-cell sequencing / vaping / vascular remodeling

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Ruiyang Ding, Xiaoke Ren, Qinglin Sun, Shiqian liu, Linyuan Huang, Zhiwei Sun, Junchao Duan. Single-Cell Transcriptomics Revealed E-Cigarettes-Induced Vascular Remodeling by Enhancing Tcf21 Expression. MedComm, 2025, 6(5): e70183 DOI:10.1002/mco2.70183

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References

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Grand View Research, E-cigarette And Vape Market Size, Share & Trends Analysis Report By Distribution Channel, By Product (Disposable, Rechargeable, Modular Devices), By Category, By Region, And Segment Forecasts, 2024-2030, Market Analysis Report (Grand View Research, 2023).

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T. A. Lieu and K. Bibbins-Domingo, “E-Cigarette Use in Adolescents and Adults—A JAMA Collection,” JAMA 332, no. 9 (2024): 709-710.

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J. J. Rose, S. Krishnan-Sarin, V. J. Exil, et al., “Cardiopulmonary Impact of Electronic Cigarettes and Vaping Products: A Scientific Statement from the American Heart Association,” Circulation 148, no. 8 (2023): 703-728.

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J. Li, L. Huynh, W. D. Cornwell, et al., “Electronic Cigarettes Induce Mitochondrial DNA Damage and Trigger TLR9 (Toll-Like Receptor 9)-Mediated Atherosclerosis,” Arteriosclerosis, Thrombosis, and Vascular Biology 41, no. 2 (2021): 839-853.

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M. Nagao, Q. Lyu, Q. Zhao, et al., “Coronary Disease-Associated Gene TCF21 Inhibits Smooth Muscle Cell Differentiation by Blocking the Myocardin-Serum Response Factor Pathway,” Circulation Research 126, no. 4 (2020): 517-529.

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R. C. Wirka, D. Wagh, D. T. Paik, et al., “Atheroprotective Roles of Smooth Muscle Cell Phenotypic Modulation and the TCF21 Disease Gene as Revealed by Single-Cell Analysis,” Nature Medicine 25, no. 8 (2019): 1280-1289.

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Y. Xie and K. A. Martin, “TCF21: Flipping the Phenotypic Switch in SMC,” Circulation Research 126, no. 4 (2020): 530-532.

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X. K. Zhao, M. M. Zhu, S. N. Wang, et al., “Transcription Factor 21 Accelerates Vascular Calcification in Mice by Activating the IL-6/STAT3 Signaling Pathway and the Interplay Between VSMCs and ECs,” Acta Pharmacologica Sinica 44, no. 8 (2023): 1625-1636.

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2025 The Author(s). MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.

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