Expanding the Scope of Molecular Glues: TRIM21 as a Multimeric Protein Degrader

Kai Huang; Anqi Zhou; Xiangxiang Zhou

doi:10.1002/mco2.70178

MedComm ›› 2025, Vol. 6 ›› Issue (5) : e70178 DOI: 10.1002/mco2.70178

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Expanding the Scope of Molecular Glues: TRIM21 as a Multimeric Protein Degrader

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Kai Huang, Anqi Zhou, Xiangxiang Zhou. Expanding the Scope of Molecular Glues: TRIM21 as a Multimeric Protein Degrader. MedComm, 2025, 6(5): e70178 DOI:10.1002/mco2.70178

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References

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[1]	P. Lu, Y. Cheng, L. Xue, et al., “Selective Degradation of Multimeric Proteins by TRIM21-based Molecular Glue and PROTAC Degraders,” Cell 187, no. 25 (2024): 7126-7142. e20.

[2]	J. M. Tsai, R. P. Nowak, B. L. Ebert, and E. S. Fischer, “Targeted Protein Degradation: From Mechanisms to Clinic,” Nature Reviews Molecular Cell Biology 25, no. 9 (2024): 740-757.

[3]	Y. Liu, J. Yang, T. Wang, et al., “Expanding PROTACtable Genome Universe of E3 Ligases,” Nature Communications 14, no. 1 (2023): 6509.

[4]	M. A. Scemama de Gialluly, A. R. Allen, E. H. Hayes, et al., “PRLX-93936 and BMS-214662 Are Cytotoxic Molecular Glues That Leverage TRIM21 to Degrade Nucleoporins,” BioRxiv (2024). 2024.12.18.629219.

[5]	Y. Cheng, L. Cao, P. Lu, et al., “TRIM21-NUP98 interface Accommodates Structurally Diverse Molecular Glue Degraders,” BioRxiv (2025). 2025.01.07.631691.

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