Stable Expressed DNMT3A Mutants Predict a Poor Prognosis in Acute Myeloid Leukemia Patients Without Receiving Hematopoietic Stem Cell Transplantation

Xiang Zhang; Lixia Liu; Jiayue Qin; Xiong Ni; Jie Jin

doi:10.1002/mco2.70151

MedComm ›› 2025, Vol. 6 ›› Issue (4) : e70151 DOI: 10.1002/mco2.70151

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Stable Expressed DNMT3A Mutants Predict a Poor Prognosis in Acute Myeloid Leukemia Patients Without Receiving Hematopoietic Stem Cell Transplantation

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Xiang Zhang, Lixia Liu, Jiayue Qin, Xiong Ni, Jie Jin. Stable Expressed DNMT3A Mutants Predict a Poor Prognosis in Acute Myeloid Leukemia Patients Without Receiving Hematopoietic Stem Cell Transplantation. MedComm, 2025, 6(4): e70151 DOI:10.1002/mco2.70151

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References

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[1]	L. Brunetti, M. C. Gundry, and M. A. Goodell, “DNMT3A in Leukemia,” Cold Spring Harbor Perspectives in Medicine 7, no. 2 (2017): a030320.

[2]	X. Zhang, A. Huang, L. Liu, et al., “The Clinical Impact of IKZF1 Mutation in Acute Myeloid Leukemia,” Experimental Hematology & Oncology 12, no. 1 (2023): 33.

[3]	X. Zhang, Z. Wang, J. Sun, et al., “New Insights Into the Clinical Characteristics of SETD2-Mutated Acute Myeloid Leukaemia,” British Journal of Haematology 202, no. 1 (2023): 111-115.

[4]	Y. H. Huang, C. W. Chen, V. Sundaramurthy, et al., “Systematic Profiling of DNMT3A Variants Reveals Protein Instability Mediated by the DCAF8 E3 Ubiquitin Ligase Adaptor,” Cancer Discovery 12, no. 1 (2022): 220-235.

[5]	Y. Xu, Y. Sun, H. Shen, et al., “Allogeneic Hematopoietic Stem Cell Transplantation Could Improve Survival of Cytogenetically Normal Adult Acute Myeloid Leukemia Patients With DNMT3A Mutations,” American Journal of Hematology 90, no. 11 (2015): 992-997.

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