Meal-Induced NF-kB Activation in Mononuclear Cells Triggers Lumican Secretion and Promotes Chronic Kidney Disease in Metabolic Dysfunction-Associated Steatotic Liver Disease

Giovanni Musso; Filippo Mariano; Alberto Mella; Silvia Pinach; Roberto Gambino

doi:10.1002/mco2.70122

MedComm ›› 2025, Vol. 6 ›› Issue (8) : e70122 DOI: 10.1002/mco2.70122

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Meal-Induced NF-kB Activation in Mononuclear Cells Triggers Lumican Secretion and Promotes Chronic Kidney Disease in Metabolic Dysfunction-Associated Steatotic Liver Disease

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Giovanni Musso, Filippo Mariano, Alberto Mella, Silvia Pinach, Roberto Gambino. Meal-Induced NF-kB Activation in Mononuclear Cells Triggers Lumican Secretion and Promotes Chronic Kidney Disease in Metabolic Dysfunction-Associated Steatotic Liver Disease. MedComm, 2025, 6(8): e70122 DOI:10.1002/mco2.70122

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References

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[1]	G. Musso, R. Gambino, J. H. Tabibian, et al., “Association of Non-Alcoholic Fatty Liver Disease With Chronic Kidney Disease: A Systematic Review and Meta-Analysis,” Plos Medicine 11 (2014): e1001680.

[2]	D. Q. Sun, G. Targher, C. D. Byrne, et al., “An International Delphi Consensus Statement on Metabolic Dysfunction-Associated Fatty Liver Disease and Risk of Chronic Kidney Disease,” Hepatobiliary Surgery and Nutrition 12 (2023): 386-403.

[3]	M. A. Hofmann, S. Schiekofer, M. Kanitz, et al., “Insufficient Glycemic Control Increases Nuclear Factor-Kappa B Binding Activity in Peripheral Blood Mononuclear Cells Isolated From Patients With Type 1 Diabetes,” Diabetes Care 21 (1998): 1310-1316.

[4]	G. Musso, S. Pinach, F. Mariano, et al., “Effect of Phospholipid Curcumin Meriva® on Liver Histology and Kidney Disease in Nonalcoholic Steatohepatitis a Randomized, Double-blind, Placebo-Controlled Trial,” Hepatology 81, no. 2 (2025): 560-575.

[5]	H. Nie, H. Yang, L. Cheng, and J. Yu, “Identification of Lipotoxicity-Related Biomarkers in Diabetic Nephropathy Based on Bioinformatic Analysis,” Journal of Diabetes Research 2024 (2024): 5550812.

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