A novel innate immunity-mediated senescence mechanism regulated by cGAS–STING–IRF3–pRB

Linbin Zhou; Jiahui Li; Wai Kit Chu

doi:10.1002/mco2.70072

MedComm ›› 2025, Vol. 6 ›› Issue (2) : e70072 DOI: 10.1002/mco2.70072

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A novel innate immunity-mediated senescence mechanism regulated by cGAS–STING–IRF3–pRB

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Linbin Zhou, Jiahui Li, Wai Kit Chu. A novel innate immunity-mediated senescence mechanism regulated by cGAS–STING–IRF3–pRB. MedComm, 2025, 6(2): e70072 DOI:10.1002/mco2.70072

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References

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[1]	Wu Q, Leng X, Zhang Q, et al. IRF3 activates RB to authorize cGAS-STING-induced senescence and mitigate liver fibrosis. Sci Adv. 2024; 10(9): eadj2102.

[2]	Chen C, Xu P. Cellular functions of cGAS-STING signaling. Trends Cell Biol. 2023; 33(8): 630-648.

[3]	Konagaya Y, Rosenthal D, Ratnayeke N, Fan Y, Meyer T. An intermediate Rb-E2F activity state safeguards proliferation commitment. Nature. 2024; 631(8020): 424-431.

[4]	Zhuang Y, Ortega-Ribera M, Thevkar Nagesh P, et al. Bile acid-induced IRF3 phosphorylation mediates cell death, inflammatory responses, and fibrosis in cholestasis-induced liver and kidney injury via regulation of ZBP1. Hepatology. 2024; 79(4): 752-767.

[5]	Zhao H, Liu Z, Chen H, et al. Identifying specific functional roles for senescence across cell types. Cell. 2024; 187(25): 7314-7334.

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