WSB2 inhibits apoptosis and autophagy by targeting NOXA for degradation

Shengpeng Shao; Danrui Cui; Chutian Zheng; Xiufang Xiong; Yongchao Zhao

doi:10.1002/mco2.70071

MedComm ›› 2025, Vol. 6 ›› Issue (2) : e70071 DOI: 10.1002/mco2.70071

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WSB2 inhibits apoptosis and autophagy by targeting NOXA for degradation

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CUL5 / degradation / NOXA / ubiquitylation / WSB2

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Shengpeng Shao, Danrui Cui, Chutian Zheng, Xiufang Xiong, Yongchao Zhao. WSB2 inhibits apoptosis and autophagy by targeting NOXA for degradation. MedComm, 2025, 6(2): e70071 DOI:10.1002/mco2.70071

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References

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[1]	Elgendy M, Sheridan C, Brumatti G, Martin SJ. Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival. Mol Cell. 2011; 42(1): 23-35.

[2]	Guikema JE, Amiot M, Eldering E. Exploiting the pro-apoptotic function of NOXA as a therapeutic modality in cancer. Expert Opin Ther Targets. 2017; 21(8): 767-779.

[3]	Zhao Y, Xiong X, Sun Y. Cullin-RING Ligase 5: functional characterization and its role in human cancers. Semin Cancer Biol. 2020; 67(Pt 2): 61-79.

[4]	Li X, Zhang CC, Lin XT, et al. Elevated expression of WSB2 degrades p53 and activates the IGFBP3-AKT-mTOR-dependent pathway to drive hepatocellular carcinoma. Exp Mol Med. 2024; 56: 177-191.

[5]	Pang X, Zhang J, Lopez H, et al. The carboxyl-terminal tail of Noxa protein regulates the stability of Noxa and Mcl-1. J Biol Chem. 2014; 289(25): 17802-17811.

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