Transient pre-seizure inhibition of lateral hypothalamic orexin neurons: a novel possibility for seizure control

Yuang Gu; Yi Wang; Heming Cheng

doi:10.1002/mco2.70070

MedComm ›› 2025, Vol. 6 ›› Issue (2) : e70070 DOI: 10.1002/mco2.70070

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Transient pre-seizure inhibition of lateral hypothalamic orexin neurons: a novel possibility for seizure control

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Yuang Gu, Yi Wang, Heming Cheng. Transient pre-seizure inhibition of lateral hypothalamic orexin neurons: a novel possibility for seizure control. MedComm, 2025, 6(2): e70070 DOI:10.1002/mco2.70070

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References

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[1]	Li HT, Viskaitis P, Bracey E, Peleg-Raibstein D, Burdakov D. Transient targeting of hypothalamic orexin neurons alleviates seizures in a mouse model of epilepsy. Nat Commun. 2024; 15(1): 1249.

[2]	Kordi Jaz E, Moghimi A, Fereidoni M, Asadi S, Shamsizadeh A, Roohbakhsh A. SB-334867, an orexin receptor 1 antagonist, decreased seizure and anxiety in pentylenetetrazol-kindled rats. Fundam Clin Pharmacol. 2017; 31(2): 201-207.

[3]	Muir J, Anguiano M, Kim CK. Neuromodulator and neuropeptide sensors and probes for precise circuit interrogation in vivo. Science. 2024; 385(6716): eadn6671.

[4]	Pantoja-Jimenez CR, Magdaleno-Madrigal VM, Almazan-Alvarado S, Fernandez-Mas R. Anti-epileptogenic effect of high-frequency stimulation in the thalamic reticular nucleus on PTZ-induced seizures. Brain Stimul. 2014; 7(4): 587-594.

[5]	Xu C, Wang Y, Zhang S, et al. Subicular pyramidal neurons gate drug resistance in temporal lobe epilepsy. Ann Neurol. 2019; 86(4): 626-640.

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