Carbonaceous particle exposure triggered accumulation of Osteopontin/SPP1+ macrophages contributes to emphysema development

Lianyong Han; Verena Haefner; Ali Onder Yildirim; Heiko Adler; Tobias Stoeger

doi:10.1002/mco2.70061

MedComm ›› 2025, Vol. 6 ›› Issue (2) : e70061 DOI: 10.1002/mco2.70061

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Carbonaceous particle exposure triggered accumulation of Osteopontin/SPP1+ macrophages contributes to emphysema development

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Lianyong Han, Verena Haefner, Ali Onder Yildirim, Heiko Adler, Tobias Stoeger. Carbonaceous particle exposure triggered accumulation of Osteopontin/SPP1+ macrophages contributes to emphysema development. MedComm, 2025, 6(2): e70061 DOI:10.1002/mco2.70061

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References

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[1]	WHO. Smoking is the leading cause of chronic obstructive pulmonary disease. 2024. Available from: https://www.who.int/news/item/15-11-2023-smoking-is-the-leading-cause-of-chronic-obstructive-pulmonary-disease

[2]	Amegadzie JE, Mehareen J, Khakban A, Joshi P, Carlsten C, Sadatsafavi M. Twenty-year trends in excess costs of chronic obstructive pulmonary disease. Eur Respir J. 2024;2400516.

[3]	Sattler C, Moritz F, Chen S, et al. Nanoparticle exposure reactivates latent herpesvirus and restores a signature of acute infection. Part Fibre Toxicol. 2017; 14(1): 2.

[4]	Han L, Haefner V, Yu Y, et al. Nanoparticle-exposure-triggered virus reactivation induces lung emphysema in mice. ACS Nano. 2023; 17(21): 21056-21072.

[5]	Andre E, Stoeger T, Takenaka S, et al. Inhalation of ultrafine carbon particles triggers biphasic pro-inflammatory response in the mouse lung. Eur Respir J. 2006; 28(2): 275-85.

[6]	Papaporfyriou A, Loukides S, Kostikas K, et al. Increased levels of osteopontin in sputum supernatant in patients with COPD. Chest. 2014; 146(4): 951-958.

[7]	Lee SJ, Kim SH, Kim W, et al. Increased plasma osteopontin in frequent exacerbator and acute exacerbation of COPD. Clin Respir J. 2014; 8(3): 305-311.

[8]	Gunes Gunsel G, Conlon TM, Jeridi A, et al. The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD. Nat Commun. 2022; 13(1): 1303.

[9]	Shan M, Yuan X, Song LZ, et al. Cigarette smoke induction of osteopontin (SPP1) mediates T(H)17 inflammation in human and experimental emphysema. Sci Transl Med. 2012; 4(117): 117ra9.

[10]	You R, Lu W, Shan M, et al. Nanoparticulate carbon black in cigarette smoke induces DNA cleavage and Th17-mediated emphysema. Elife. 2015; 4: e09623.

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