Redefining DNA cleavage in type I CRISPR systems with the HNH domain

Senfeng Zhang; Yao Liu; Chunyi Hu

doi:10.1002/mco2.70060

MedComm ›› 2025, Vol. 6 ›› Issue (2) : e70060 DOI: 10.1002/mco2.70060

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Redefining DNA cleavage in type I CRISPR systems with the HNH domain

Senfeng Zhang ¹
, Yao Liu ¹
, Chunyi Hu ¹^,²^,³^,^†

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Senfeng Zhang, Yao Liu, Chunyi Hu. Redefining DNA cleavage in type I CRISPR systems with the HNH domain. MedComm, 2025, 6(2): e70060 DOI:10.1002/mco2.70060

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References

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[1]	Hirano S, Altae-Tran H, Kannan S, Macrae RK, Zhang F. Structural determinants of DNA cleavage by a CRISPR HNH-Cascade system. Mol Cell, 2024; 84(16): 3154-3162. e3155.

[2]	Zhang C, Chen F, Wang F, Xu H, Xue J, Li Z. Mechanisms for HNH-mediated target DNA cleavage in type I CRISPR-Cas systems. Mol Cell. 2024; 84(16): 3141-3153. e3145.

[3]	Altae-Tran H, Kannan S, Suberski AJ, et al. Uncovering the functional diversity of rare CRISPR-Cas systems with deep terascale clustering. Science. 2023; 382(6673): eadi1910.

[4]	Makarova KS, Wolf YI, Iranzo J, et al. Evolutionary classification of CRISPR-Cas systems: a burst of class 2 and derived variants. Nat Rev Microbiol. 2020; 18(2): 67-83.

[5]	Hu C, Ni D, Nam KH, et al. Allosteric control of type I-A CRISPR-Cas3 complexes and establishment as effective nucleic acid detection and human genome editing tools. Mol Cell. 2022; 82(15): 2754-2768. e2755.

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