HCoV-HKU1 and TMPRSS2 interaction: uncovering mechanisms of viral invasion

Zehan Pang; Huahao Fan; Xiaolong Xu

doi:10.1002/mco2.70051

MedComm ›› 2025, Vol. 6 ›› Issue (1) : e70051 DOI: 10.1002/mco2.70051

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HCoV-HKU1 and TMPRSS2 interaction: uncovering mechanisms of viral invasion

Zehan Pang ¹
, Huahao Fan ¹^,^†
, Xiaolong Xu ²^,^†

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Zehan Pang, Huahao Fan, Xiaolong Xu. HCoV-HKU1 and TMPRSS2 interaction: uncovering mechanisms of viral invasion. MedComm, 2025, 6(1): e70051 DOI:10.1002/mco2.70051

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References

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[1]	McCallum M, Park YJ, Stewart C, et al. Human coronavirus HKU1 recognition of the TMPRSS2 host receptor. Cell. 2024; 187(16): 4231-4245. e13.

[2]	Wang H, Liu X, Zhang X, et al. TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry. Cell. 2024; 187(16): 4261-4271. e17.

[3]	Fernández I, Saunders N, Duquerroy S, et al. Structural basis of TMPRSS2 zymogen activation and recognition by the HKU1 seasonal coronavirus. Cell. 2024; 187(16): 4246-4260. e16.

[4]	Hulswit R, Lang Y, Bakkers M, et al. Human coronaviruses OC43 and HKU1 bind to 9-O-acetylated sialic acids via a conserved receptor-binding site in spike protein domain A. Proc Natl Acad Sci USA. 2019; 116(7): 2681-2690.

[5]	Saunders N, Fernandez I, Planchais C, et al. TMPRSS2 is a functional receptor for the human coronavirus HKU1. Nature. 2023; 624(7990): 207-214.

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2025 The Author(s). MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.