Sag deletion promotes DMBA/TPA-induced skin carcinogenesis via YAP accumulation

Yi Sun; Jie Xu; Dongping Wei; Hua Li

doi:10.1002/mco2.648

MedComm ›› 2024, Vol. 5 ›› Issue (8) : e648 DOI: 10.1002/mco2.648

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Sag deletion promotes DMBA/TPA-induced skin carcinogenesis via YAP accumulation

Yi Sun ¹^,²^,^†
, Jie Xu ³
, Dongping Wei ³
, Hua Li ³

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Yi Sun, Jie Xu, Dongping Wei, Hua Li. Sag deletion promotes DMBA/TPA-induced skin carcinogenesis via YAP accumulation. MedComm, 2024, 5(8): e648 DOI:10.1002/mco2.648

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References

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[1]	Gu Q, Bowden GT, Normolle D, Sun Y. SAG/ROC2 E3 ligase regulates skin carcinogenesis by stage-dependent targeting of c-Jun/AP1 and IkappaB-alpha/NF-kappaB. J Cell Biol. 2007; 178(6): 1009-1023.

[2]	Li H, Tan M, Jia L, et al. Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis. J Clin Invest. 2014; 124(2): 835-846.

[3]	Tan M, Chang Y, Liu X, et al. The Sag-Shoc2 axis regulates conversion of mPanINs to cystic lesions in Kras pancreatic tumor model. Cell Rep. 2022; 41(12): 111837.

[4]	Xie CM, Wei D, Zhao L, et al. Erbin is a novel substrate of the Sag-betaTrCP E3 ligase that regulates KrasG12D-induced skin tumorigenesis. J Cell Biol. 2015; 209(5): 721-737.

[5]	Zhang Q, Wei D, Tan M, Li H, Morgan MA, Sun Y. Transgenic expression of Sag/Rbx2 E3 causes early stage tumor promotion, late stage cytogenesis and acinar loss in the Kras-PDAC model. Neoplasia. 2020; 22(6): 242-252.

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