Engineered CARD11–PIK3R3 T-cell therapies as weapons of cancer mass destruction

Wanlu Zhang1, Min Wu2,3(), Yongye Huang1,3()

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MedComm ›› 2024, Vol. 5 ›› Issue (7) : e628. DOI: 10.1002/mco2.628
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Engineered CARD11–PIK3R3 T-cell therapies as weapons of cancer mass destruction

  • Wanlu Zhang1, Min Wu2,3(), Yongye Huang1,3()
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Wanlu Zhang, Min Wu, Yongye Huang. Engineered CARD11–PIK3R3 T-cell therapies as weapons of cancer mass destruction. MedComm, 2024, 5(7): e628 https://doi.org/10.1002/mco2.628

References

1 J Garcia, J Daniels, Y Lee, et al. Naturally occurring T cell mutations enhance engineered T cell therapies. Nature. 2024;626(7999):626-634.
2 EA Stadtmauer, JA Fraietta, MM Davis, et al. CRISPR-engineered T cells in patients with refractory cancer. Science. 2020;367(6481):eaba7365.
3 J Middelburg, M Sluijter, G Schaap, et al. T-cell stimulating vaccines empower CD3 bispecific antibody therapy in solid tumors. Nat Commun. 2024;15(1):48.
4 R Eferl, EF Wagner. AP-1: a double-edged sword in tumorigenesis. Nat Rev Cancer. 2003;3(11):859-868.
5 KPM Suijkerbuijk, MJM van Eijs, F van Wijk, AMM Eggermont. Clinical and translational attributes of immune-related adverse events. Nat Cancer. 2024;5(4):557-571.
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