Deleting SUV39H1 in CAR-T cells epigenetically enhances the antitumor function

Yuning Wang, Guo Zhao, Shuhang Wang(), Ning Li()

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MedComm ›› 2024, Vol. 5 ›› Issue (5) : e552. DOI: 10.1002/mco2.552
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Deleting SUV39H1 in CAR-T cells epigenetically enhances the antitumor function

  • Yuning Wang, Guo Zhao, Shuhang Wang(), Ning Li()
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Yuning Wang, Guo Zhao, Shuhang Wang, Ning Li. Deleting SUV39H1 in CAR-T cells epigenetically enhances the antitumor function. MedComm, 2024, 5(5): e552 https://doi.org/10.1002/mco2.552

References

1 N Jain, Z Zhao, RP Koche, et al. Disruption of SUV39H1-mediated H3K9 methylation sustains CAR T-cell function. Cancer Discov. 2024;14(1):142-157.
2 S Lopez-Cobo, JR Fuentealba, P Gueguen, et al. SUV39H1 ablation enhances long-term CAR T function in solid tumors. Cancer Discov. 2024;14(1):120-141.
3 OK Dagher. Forks in the road for CAR T and CAR NK cell cancer therapies. Nat Immunol. 2023;24(12):1994-2007.
4 L Fang, Y Hao, H Yu, et al. Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity. Cancer Cell. 2023;41(6):e12.
5 LL Niborski, P Gueguen, M Ye, et al. CD8+T cell responsiveness to anti-PD-1 is epigenetically regulated by Suv39h1 in melanomas. Nat Commun. 2022;13(1):3739.
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