S-adenosyl methionine-AMP opens another skylight of CRISPR system: discovering novel second messenger for bacterial antiviral immunity

Yongye Huang1(), Sihui Zhang1, Min Wu2,3()

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MedComm ›› 2024, Vol. 5 ›› Issue (5) : e522. DOI: 10.1002/mco2.522
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S-adenosyl methionine-AMP opens another skylight of CRISPR system: discovering novel second messenger for bacterial antiviral immunity

  • Yongye Huang1(), Sihui Zhang1, Min Wu2,3()
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antiviral / CRISPR / second messenger

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Yongye Huang, Sihui Zhang, Min Wu. S-adenosyl methionine-AMP opens another skylight of CRISPR system: discovering novel second messenger for bacterial antiviral immunity. MedComm, 2024, 5(5): e522 https://doi.org/10.1002/mco2.522

References

1 H Chi, V Hoikkala, S Grüschow, et al. Antiviral type III CRISPR signalling via conjugation of ATP and SAM. Nature. 2023;622(7984):826-833.
2 S Doron, S Melamed, G Ofir, et al. Systematic discovery of antiphage defense systems in the microbial pangenome. Science. 2018;359(6379):1-11.
3 SPB van Beljouw, J Sander, A Rodriguez-Molina, et al. RNA-targeting CRISPR-Cas systems. Nat Rev Microbiol. 2023;21(1):21-34.
4 SJ Hobbs, T Wein, A Lu, et al. Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity. Nature. 2022;605(7910):522-526.
5 S Camara-Wilpert, D Mayo-Mu?oz, J Russel, et al. Bacteriophages suppress CRISPR-Cas immunity using RNA-based anti-CRISPRs. Nature. 2023;623(7987):601-607.
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