From seq-ing to modeling: towards a molecular understanding of special properties of immature neurons in the human hippocampus

Taosha Gao; Yuki Fujita; Yixing Chen; Zetian Wang; Yisha Lu; Dongchang Huang; Jingting Shen; Longying Yan; Shiyi Zhang; Yuxuan Wang; Peiming Li; Xiang Fang; Erik Hrabovszky; Chun Xu; Yijing Su; Yang Li; Lei Zhang; Yi Zhou

doi:10.1093/lifemedi/lnaf031

Life Medicine ›› 2025, Vol. 4 ›› Issue (6) :lnaf031 DOI: 10.1093/lifemedi/lnaf031

Research Highlight

From seq-ing to modeling: towards a molecular understanding of special properties of immature neurons in the human hippocampus

Author information +

¹. Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China

². Department of Anatomy and Developmental Biology, Faculty of Medicine, Shimane University, Izumo City, Shimane 693-8501, Japan

³. State Key Laboratory of Cell Biology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China

⁴. University of the Chinese Academy of Sciences, Shanghai 200031, China

⁵. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

⁶. Department of Oral Medicine, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States

⁷. Laboratory of Reproductive Neurobiology, HUN-REN Institute of Experimental Medicine, Budapest 1083, Hungary

⁸. Sheng Yushou Center of Cell Biology and Immunology, Department of Genetics and Developmental Science, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China

yijingsu@upenn.edu (Y.S.)

liyang@simm.ac.cn (Y.Li)

rayzhang@sjtu.edu.cn (L.Z.)

zhouyi@ion.ac.cn (Y.Z.)

Show less

History +

PDF (1864KB)

Cite this article

Download citation ▾

Taosha Gao, Yuki Fujita, Yixing Chen, Zetian Wang, Yisha Lu, Dongchang Huang, Jingting Shen, Longying Yan, Shiyi Zhang, Yuxuan Wang, Peiming Li, Xiang Fang, Erik Hrabovszky, Chun Xu, Yijing Su, Yang Li, Lei Zhang, Yi Zhou. From seq-ing to modeling: towards a molecular understanding of special properties of immature neurons in the human hippocampus. Life Medicine, 2025, 4(6): lnaf031 DOI:10.1093/lifemedi/lnaf031

登录浏览全文

4963

注册一个新账户忘记密码

References

Publishing order | Descend order by publishing year | Descend order by cited within

[1]	Ming GL , Song H . Adult neurogenesis in the mammalian brain:significant answers and significant questions. Neuron 2011; 70: 687- 702.

[2]	Kempermann G , Gage FH , Aigner L et al. Human adult neurogenesis: evidence and remaining questions. Cell Stem Cell 2018; 23: 25- 30.

[3]	Sorrells SF , Paredes MF , Cebrian-Silla A et al. Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults. Nature 2018; 555: 377- 81.

[4]	Moreno-Jiménez EP , Flor-García M , Terreros-Roncal J et al. Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer's disease. Nat Med 2019; 25: 554- 60.

[5]	Zhou Y , Su Y , Li S et al. Molecular landscapes of human hippocampal immature neurons across lifespan. Nature 2022; 607: 527- 33.

[6]	Zhou Y , Su Y , Yang Q et al. Cross-species analysis of adult hippocampal neurogenesis reveals human-specific gene expression but convergent biological processes. Nat Neurosci 2025; 28: 1820- 9.

[7]	Dumitru I , Paterlini M , Zamboni M et al. Identification of proliferating neural progenitors in the adult human hippocampus. Science (1979) 2025; 389: 58- 63.

[8]	Zhou Y , Song H , Ming GL . Genetics of human brain development. Nat Rev Genet 2024; 25: 26- 45.

[9]	Kohler SJ , Williams NI , Stanton GB et al. Maturation time of new granule cells in the dentate gyrus of adult macaque monkeys exceeds six months. Proc Natl Acad Sci USA 2011; 108: 10326- 31.

[10]	Ngwenya LB , Heyworth NC , Shwe Y et al. Age-related changes in dentate gyrus cell numbers, neurogenesis, and associations with cognitive impairments in the rhesus monkey. Front Syst Neurosci 2015; 9: 102.