A framework of biomarkers for adipose tissue aging: a consensus statement by the Aging Biomarker Consortium

Aging Biomarker Consortium; Jian Yu; Yankang Zhang; Ting Zhang; Yan Bi; Yan Chen; Zheng Chen; Zhe Dai; Feifan Guo; Lixin Guo; Cheng Hu; Xiangqing Kong; Jian Li; Pingsheng Liu; Yong Liu; Jing Qu; Qiqun Tang; Congyi Wang; Liheng Wang; Jiqiu Wang; Jianping Weng; Aimin Xu; Lingyan Xu; Huijie Zhang; Jiajun Zhao; Jingjing Zhang; Weiqi Zhang; Tongjin Zhao; Weiping Zhang; Zhiming Zhu; GuangHui Liu; Guang Ning; Gang Pei; Li Qiang; Feng Liu; Xinran Ma

doi:10.1093/lifemedi/lnaf027

Life Medicine ›› 2025, Vol. 4 ›› Issue (5) :lnaf027 DOI: 10.1093/lifemedi/lnaf027

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A framework of biomarkers for adipose tissue aging: a consensus statement by the Aging Biomarker Consortium

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¹. School of Life Sciences, East China Normal University, Shanghai 200241, China

². Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, China

³. Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai 200031, China

⁴. School of Life Science and Technology, Harbin Institute of Technology, Harbin 150001, China

⁵. Endocrinology Department of Zhongnan Hospital, Wuhan University, Wuhan 430071, China

⁶. Institute for Translational Brain Research, Fudan University, Shanghai 200032, China

⁷. Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China

⁸. Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China

⁹. The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

¹⁰. Institute of Geriatric Medicine, Beijing Hospital, Beijing 100730, China

¹¹. Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China

¹². College of Life Sciences, Wuhan University, Wuhan 430072, China

¹³. Beijing Institute of Stem Cell and Regenerative Medicine, Beijing 100101, China

¹⁴. School of Basic Medical Sciences, Fudan University, Shanghai 200032, China

¹⁵. Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

¹⁶. Institute of Cardiovascular Sciences, Peking University, Beijing 100191, China

¹⁷. Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

¹⁸. Anhui Medical University, Hefei 230032, China

¹⁹. School of Clinical Medicine, The University of Hong Kong, Hong Kong 999077, China

²⁰. Nanfang Hospital, Southern Medical University, Guangzhou 510515, China

²¹. Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China

²². The Second Xiangya Hospital of Central South University, Changsha 410011, China

²³. Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China

²⁴. Academy of Medical Sciences, Zhengzhou University, Zhengzhou 450001, China

²⁵. School of Basic Medical Sciences, Naval Medical University, Shanghai 200433, China

²⁶. Daping Hospital, Army Medical University, Chongqing 400042, China

²⁷. Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

²⁸. College of Life Sciences and Technology, Tongji University, Shanghai 200092, China

²⁹. School of Basic Medical Sciences, Peking University, Beijing 100191, China

³⁰. Institute for Aging, East China Normal University, Shanghai 200062, China

biyan@nju.edu.cn (Y.B.)

ychen3@sibs. ac.cn (Y.C.)

chenzheng@hit.edu.cn (Z.C.)

daizhe@znhospital. cn (Z.D.)

ffguo@fudan.edu.cn (F.G.)

glxwork2016@163.com (L.G.)

alfredhc@sjtu.edu.cn (C.H.)

Kongxq@njmu.edu.cn (X.K.)

lijian@bjhmoh.cn (J.L.)

pliu@ibp.ac.cn (P.L.)

liuyong31279@whu.edu.cn (Y.L.)

qujing@ioz.ac.cn (J.Q.)

qqtang@shmu.edu. cn (Q.T.)

wangcy@tjh.tjmu.edu.cn (C.W.)

lihengwang@hsc. pku.edu.cn (L.W.)

wangjq@shsmu.edu.cn (J.W.)

wengjp@ustc.edu.cn (J.W.)

amxu@hku.hk (A.X.)

lyxu@bio.ecnu.edu. cn (L.X.)

huijiezhang2005@126.com (H.Z.)

jjzhao@sdu.edu. cn (J.Z.)

Doctorzhangjj@csu.edu.cn (J.Z.)

zhangwq@big.ac.cn (W.Z.)

zhaotj@fudan.edu.cn (T.Z.)

wzhang@smmu.edu.cn (W.Z.)

hbpcms@sina.com (Z.Z.)

ghliu@ioz.ac.cn (G.-H.L.)

gning@sibs. ac.cn (G.N.)

peigang@tongji.edu.cn (G.P.)

qiang@hsc.pku.edu.cn (L.Q.)

liuf001@csu.edu.cn (F.L.)

xrma@bio.ecnu.edu.cn (X.M.)

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Abstract

Adipose tissue serves as a crucial energy storage and metabolic organ in the human body. With the surging of elderly population in China comes significant challenges in preventing and managing age-associated diseases, while adipose tissue aging represents one of the pivotal initiating events for multi-organ senescence. To address these challenges, the Aging China Biomarkers Consortium (ABC) has established an expert consensus on biomarkers of adipose tissue aging by digesting literature and collecting insights from scientists and clinicians. This consensus provides a comprehensive evaluation of the key changes and characteristics, as well as biomarkers related to adipose tissue aging and proposes a systematic framework categorizing these biomarkers into functional, structural and humoral dimensions. Within each dimension, the ABC recommends clinically and empirically validated biomarkers and parameters for assessing both physiological and pathological changes in adipose tissue during aging, which aims to establish a foundation for future prediction, diagnosis, early warning and treatment for adipose tissue aging and its related diseases, with the ultimate goal of improving adipose tissue health and promoting healthy aging in elderly populations both in China and worldwide.

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Aging Biomarker Consortium, Jian Yu, Yankang Zhang, Ting Zhang, Yan Bi, Yan Chen, Zheng Chen, Zhe Dai, Feifan Guo, Lixin Guo, Cheng Hu, Xiangqing Kong, Jian Li, Pingsheng Liu, Yong Liu, Jing Qu, Qiqun Tang, Congyi Wang, Liheng Wang, Jiqiu Wang, Jianping Weng, Aimin Xu, Lingyan Xu, Huijie Zhang, Jiajun Zhao, Jingjing Zhang, Weiqi Zhang, Tongjin Zhao, Weiping Zhang, Zhiming Zhu, GuangHui Liu, Guang Ning, Gang Pei, Li Qiang, Feng Liu, Xinran Ma. A framework of biomarkers for adipose tissue aging: a consensus statement by the Aging Biomarker Consortium. Life Medicine, 2025, 4(5): lnaf027 DOI:10.1093/lifemedi/lnaf027

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