Lysozyme alleviates DSS-induced colitis by modulating pro-inflammatory factors and NF-κB activation

Kai Wang; Lan Guo; Ting Wang; Fengmin Shi; Meihong Fu; Guojun Li; Songli Pan; Xianying Cao; Huanxiong Chen

doi:10.1093/lifemedi/lnaf020

Life Medicine ›› 2025, Vol. 4 ›› Issue (5) :lnaf020 DOI: 10.1093/lifemedi/lnaf020

Letter

Lysozyme alleviates DSS-induced colitis by modulating pro-inflammatory factors and NF-κB activation

Author information +

History +

PDF (2869KB)

Cite this article

Download citation ▾

Kai Wang, Lan Guo, Ting Wang, Fengmin Shi, Meihong Fu, Guojun Li, Songli Pan, Xianying Cao, Huanxiong Chen. Lysozyme alleviates DSS-induced colitis by modulating pro-inflammatory factors and NF-κB activation. Life Medicine, 2025, 4(5): lnaf020 DOI:10.1093/lifemedi/lnaf020

登录浏览全文

4963

注册一个新账户忘记密码

References

Publishing order | Descend order by publishing year | Descend order by cited within

[1]	Abraham C , Cho JH . Inflammatory bowel disease. N Engl J Med 2009; 361: 2066- 78.

[2]	Ungaro R , Mehandru S , Allen PB , et al. Ulcerative colitis. Lancet (London, England) 2017; 389: 1756- 70.

[3]	Ma C , Jairath V , Feagan BG , et al. Interpreting modern randomized controlled trials of medical therapy in inflammatory bowel disease. Nat Rev Gastroenterol Hepatol 2024; 21: 792- 808.

[4]	Honap S , Jairath V , Sands BE , et al. Acute severe ulcerative colitis trials:the past, the present and the future. Gut 2024; 73: 1763- 73.

[5]	Veerasubramanian PK , Wynn TA , Quan J , et al. Targeting TNF/ TNFR superfamilies in immune-mediated inflammatory diseases. J Exp Med 2024; 221: e20240806.

[6]	Zigdon M , Bel S . Lysozyme:a double-edged sword in the intestine. Trends Immunol 2020; 41: 1054- 6.

[7]	Yu S , Balasubramanian I , Laubitz D , et al. Paneth cell-derived lysozyme defines the composition of mucolytic microbiota and the inflammatory tone of the intestine. Immunity 2020; 53: 398- 416.e8.

[8]	Dalmasso G , Charrier-Hisamuddin L , Thu Nguyen HT , et al. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterol 2009; 134: 166- 78.

[9]	Larsen IS , Jensen BAH , Bonazzi E , et al. Fungal lysozyme leverages the gut microbiota to curb DSS-induced colitis. Gut Microbes 2021; 13: 1988836.

[10]	Ahlawat S , Kumar P , Mohan H , et al. Inflammatory bowel disease:tri-directional relationship between microbiota, immune system and intestinal epithelium. Crit Rev Microbiol 2021; 47: 254- 73.