Identification of deferasirox as a human xanthine oxidase inhibitor

Yunfei Qi , Xinheng He , Xiaoshan Wu , Tingting Zhou , Ningning Liang , Jiazheng Jiao , Yanhao Chen , Yue Yuan , Yuwei Zhang , Yucheng Wang , Yan Liu , Qiurong Ding

Life Medicine ›› 2025, Vol. 4 ›› Issue (2) : lnaf014

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Life Medicine ›› 2025, Vol. 4 ›› Issue (2) : lnaf014 DOI: 10.1093/lifemedi/lnaf014
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Identification of deferasirox as a human xanthine oxidase inhibitor

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Yunfei Qi, Xinheng He, Xiaoshan Wu, Tingting Zhou, Ningning Liang, Jiazheng Jiao, Yanhao Chen, Yue Yuan, Yuwei Zhang, Yucheng Wang, Yan Liu, Qiurong Ding. Identification of deferasirox as a human xanthine oxidase inhibitor. Life Medicine, 2025, 4(2): lnaf014 DOI:10.1093/lifemedi/lnaf014

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Naderi M , Sadeghi-Bojd S , Valeshabad AK , et al. A prospective study of tubular dysfunction in pediatric patients with Beta thalassemia major receiving deferasirox. Pediatr Hematol Oncol 2013; 30: 748- 54.

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Yacobovich J , Stark P , Barzilai-Birenbaum S , et al. Acquired proximal renal tubular dysfunction in β-thalassemia patients treated with deferasirox. J Pediatr Hematol Oncol 2010; 32: 564- 7.

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Wei HY , Yang CP , Cheng CH , et al. Fanconi syndrome in a patient with β-thalassemia major after using deferasirox for 27 months. Transfusion 2011; 51: 949- 54.

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