A biomarker framework for auditory system aging: the Aging Biomarker Consortium consensus statement

Aging Biomarker Consortium; Xiaolong Fu; Si Wang; Yunhao Wu; Yu Sun; Wenwen Liu; Xin Xi; Geng-Lin Li; Ke Liu; Wei Yuan; Fangyi Chen; Hongyang Wang; Tao Yang; Yuhe Liu; Jialin Zheng; Haibo Shi; Jing Qu; Xiaowei Chen; Limin Suo; Yideng Huang; Xinbo Xu; Xuxia Tang; Xiaojun Li; Lei Xu; Xia Gao; Lisheng Yu; Yilai Shu; Weiqi Zhang; Jinpeng Sun; Huijun Yuan; Shusheng Gong; Wenyan Li; Xiulan Ma; Dingjun Zha; Jiangang Gao; Huawei Li; Zuhong He; Guang-Hui Liu; Gang Pei; Weijia Kong; Haibo Wang; Renjie Chai

doi:10.1093/lifemedi/lnaf011

Life Medicine ›› 2025, Vol. 4 ›› Issue (1) : lnaf011 DOI: 10.1093/lifemedi/lnaf011

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A biomarker framework for auditory system aging: the Aging Biomarker Consortium consensus statement

Aging Biomarker Consortium
, Xiaolong Fu ¹
, Si Wang ²^,³
, Yunhao Wu ¹
, Yu Sun ⁴
, Wenwen Liu ⁵
, Xin Xi ⁶^,^†
, Geng-Lin Li ⁷^,^†
, Ke Liu ⁸^,^†
, Wei Yuan ⁹^,^†
, Fangyi Chen ¹⁰^,^†
, Hongyang Wang ¹¹^,¹²^,¹³^,^†
, Tao Yang ¹⁴^,^†
, Yuhe Liu ¹⁵^,^†
, Jialin Zheng ¹⁶^,^†
, Haibo Shi ¹⁷^,^†
, Jing Qu ¹⁸^,^†
, Xiaowei Chen ¹⁹^,^†
, Limin Suo ²⁰^,^†
, Yideng Huang ²¹^,^†
, Xinbo Xu ²²^,^†
, Xuxia Tang ²³^,^†
, Xiaojun Li ²⁴^,^†
, Lei Xu ²⁵^,^†
, Xia Gao ²⁶^,^†
, Lisheng Yu ²⁷^,^†
, Yilai Shu ²⁸^,^†
, Weiqi Zhang ²⁹^,³⁰^,^†
, Jinpeng Sun ³¹^,^†
, Huijun Yuan ³²^,^†
, Shusheng Gong ³³^,^†
, Wenyan Li ³⁴^,^†
, Xiulan Ma ³⁵^,^†
, Dingjun Zha ³⁶^,^†
, Jiangang Gao ³⁷^,^†
, Huawei Li ³⁴^,^†
, Zuhong He ³⁸^,^†
, Guang-Hui Liu ³⁹^,^†
, Gang Pei ⁴⁰^,^†
, Weijia Kong ⁴¹^,^†
, Haibo Wang ⁵^,^†
, Renjie Chai ⁴²^,⁴³^,⁴⁴^,^†

Author information +

¹. Shandong Provincial Hospital, Medical Science and Technology Innovation Center, School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, China

². Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China

³. Aging Translational Medicine Center, Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital, Capital Medical University, Beijing 100053, China

⁴. Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, China

⁵. Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan 250022, China

⁶. Department of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Beijing 100000, China

⁷. ENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, Shanghai 200433, China

⁸. Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital of Capital Medical University, Beijing 100050, China

⁹. Department of Otolaryngology & Head and Neck, Chongqing General Hospital, Chongqing 401147, China

¹⁰. Department of Biology, South University of Science and Technology of China, Shenzhen 518000, China

¹¹. Senior Department of Otolaryngology Head and Neck Surgery, the sixth Medical Center of Chinese PLA General Hospital, Medical School of Chinese PLA, Beijing 100853, China

¹². State Key Laboratory of Hearing and Balance Science, Beijing 100853, China

¹³. National Clinical Research Center for Otolaryngologic Diseases, Beijing 100853, China

¹⁴. Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200023, China

¹⁵. Department of Otolaryngology, Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

¹⁶. Collaborative Innovation Center for Brain Science, Tongji University, Shanghai 200092, China

¹⁷. Department of Otolaryngology Head & Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China

¹⁸. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Institute for Stem Cell and Regeneration, Institute for Stem Cell and Regenerative Medicine, University of Chinese Academy of Sciences, Beijing 100101, China

¹⁹. Department of Otolaryngology, Peking Union Medical College Hospital, Beijing 100730, China

²⁰. Department of Otolaryngology, Head and Neck Surgery, the Second Hospital of Shanxi Medical University, Taiyuan 030001, China

²¹. Department of Otolaryngology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China

²². Department of Otolaryngology, Qilu Hospital of Shandong University, Jinan 250012, China

²³. Otolaryngology Department, Zhejiang Provincial Hospital of TCM, Hangzhou 310003, China

²⁴. Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China

²⁵. Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan 250022, China

²⁶. Department of Otolaryngology-Head and Neck Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu Provincial Key Medical Discipline (Laboratory), Nanjing 210008, China

²⁷. Department of Otolaryngology, Head and Neck Surgery, People's Hospital, Peking University, Beijing 100044, China

²⁸. ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, MOE Engineering Research Center of Gene Technology, Fudan University, Shanghai 200031, China

²⁹. China National Center for Bioinformation, Beijing 100101, China

³⁰. Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China

³¹. NHC Key Laboratory of Otorhinolaryngology, Qilu hospital and School of Basic Medical Sciences, Shandong University, Jinan 250012, China

³². Department of Oto-Rhino-Laryngology, West China Hospital, Sichuan University, Chengdu 610000, China

³³. Department of Otolaryngology-Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

³⁴. ENT institute and Otorhinolaryngology Department of Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200031, China

³⁵. Department of Otolaryngology Head and Neck Surgery, Shengjing Hospital of China Medical University, Shenyang 110000, China

³⁶. Department of Otolaryngology Head and Neck Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710000, China

³⁷. School of Life Science and Key Laboratory of the Ministry of Education for Experimental Teratology, Shandong University, Jinan 250100, China

³⁸. Department of Otorhinolaryngology-Head and Neck Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China

³⁹. State Key Laboratory of Membrane Biology, Institute of Zoology, Institute for Stem Cell and Regeneration, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100101, China

⁴⁰. Collaborative Innovation Center for Brain Science, School of Life Science and Technology, Tongji University, Shanghai 200092, China

⁴¹. Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

⁴². State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing 210096, China

⁴³. Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China

⁴⁴. School of medical technology, Institute of Engineering Medicine, Beijing Institute of Technology, Beijing 100081, China

xxi@bbn.cn (X.X.)

genglin.li@fdeent.org (G.-L.L)

liuke@ccmu.edu.cn (K.L.)

yuanwei@ucas.ac.cn (W.Y.)

chenfy@sustech.edu.cn (F.C.)

whyx301@foxmail.com (H.W.)

yangtfxl@sina. com (T.Y.)

liuyuhefeng@163.com (Y.L.)

jialinzheng@tongji.edu.cn (J.Z.)

hbshi@sjtu.edu.cn (H.S.)

qujing@ioz.ac.cn (J.Q.)

chenxw_pumch@163.com (X.C.)

suolimin@sxmu.edu.cn (L.S.)

huangyideng@wmu.edu.cn (Y.H.)

xuxinbo@sdu.edu.cn (X.X.)

20033002@zcmu.edu. cn (X.T.)

lixiaojun4183@xjtu.edu.cn (X.L.)

sdphxl@email.sdu.edu.cn (L.X.)

gaoxia@nju.edu.cn (X.G.)

yulish68@163.com (L.Y.)

yilai_shu@fudan.edu.cn (Y.S.)

zhangwq@big.ac.cn (W.Z.)

sunjinpeng@sdu.edu. cn (J.S.)

yuanhj301@163.com (H.Y.)

gongss1962@163.com (S.G.)

wenyan_li@fudan.edu.cn (W.L.)

Xiulan_ma1964@163.com (X.M.)

zhadjun@fmmu.edu.cn (D.Z.)

jggao@sdu.edu.cn (J.G.)

hwli@shmu. edu.cn (H.L.)

hezuhong@163.com (Z.H.)

ghliu@ioz.ac.cn (G.-H.L.)

peigang@tongji.edu.cn (G.P.)

entwjkong@hust.edu.cn (W.K.)

whboto11@email.sdu.edu.cn (H.W.)

renjiec@seu.edu.cn (R.C.)

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Abstract

Hearing is one of the most vital sensory functions in human beings and a crucial means of perceiving and acquiring information from the natural environment. The advancement of human society is closely linked to the development of language, with hearing serving as the foundation for verbal communication. As individuals age, the deterioration of the auditory system becomes a significant factor contributing to sensory impairments in the elderly. In addition to hearing loss, the aging of the auditory system is also associated with cognitive decline and psychosocial disorders, which severely impact the quality of life for older adults. Currently, there are no effective treatments or interventions available for addressing the aging of the auditory system. Therefore, identifying biomarkers of the auditory system aging is of great significance. The Aging Biomarker Consortium of China has conducted a comprehensive evaluation of aging biomarkers in the auditory system, focusing on three dimensions: morphological, functional, and humoral biomarkers. This initiative aims to establish a foundation for assessing the degree of aging in the auditory system and to promote the management of auditory health in an aging society, ultimately enhancing the auditory health of the elderly population both in China and globally.

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Aging Biomarker Consortium, Xiaolong Fu, Si Wang, Yunhao Wu, Yu Sun, Wenwen Liu, Xin Xi, Geng-Lin Li, Ke Liu, Wei Yuan, Fangyi Chen, Hongyang Wang, Tao Yang, Yuhe Liu, Jialin Zheng, Haibo Shi, Jing Qu, Xiaowei Chen, Limin Suo, Yideng Huang, Xinbo Xu, Xuxia Tang, Xiaojun Li, Lei Xu, Xia Gao, Lisheng Yu, Yilai Shu, Weiqi Zhang, Jinpeng Sun, Huijun Yuan, Shusheng Gong, Wenyan Li, Xiulan Ma, Dingjun Zha, Jiangang Gao, Huawei Li, Zuhong He, Guang-Hui Liu, Gang Pei, Weijia Kong, Haibo Wang, Renjie Chai. A biomarker framework for auditory system aging: the Aging Biomarker Consortium consensus statement. Life Medicine, 2025, 4(1): lnaf011 DOI:10.1093/lifemedi/lnaf011

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