Perspectives on the essence and drivers of aging

Haim Y. Cohen; Vera Gorbunova; Steve Horvath; Brian K. Kennedy; Wei Li; João Pedro de Magalhães; Andrei Seluanov; Moshi Song; Keiichiro Suzuki

doi:10.1093/lifemedi/lnaf006

Life Medicine ›› 2025, Vol. 4 ›› Issue (2) : lnaf006 DOI: 10.1093/lifemedi/lnaf006

Editorial

Perspectives on the essence and drivers of aging

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¹. The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel

². Department of Biology, University of Rochester, Rochester, NY 14627, United States

³. Department of Medicine, University of Rochester Medical Center, Rochester, NY 14627, United States

⁴. Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, United States

⁵. Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore

⁶. State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

⁷. Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China

⁸. Genomics of Ageing and Rejuvenation Lab, Institute of Inflammation and Ageing, University of Birmingham, Birmingham B15 2TT, United Kingdom

⁹. Institute for Advanced Co-Creation Studies, Osaka University, Osaka 560-8531, Japan

¹⁰. Graduate School of Engineering Science, Osaka University, Osaka 560-8531, Japan

¹¹. Graduate School of Frontier Bioscience, Osaka University, Osaka 565-0871, Japan

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Abstract

Aging is commonly associated with the decline in the function of tissues and organs, along with increased prevalence of age-related diseases. At the "International Symposium on Aging and Rejuvenation" hosted by the Institute of Zoology, Chinese Academy of Sciences, a panel of experts convened to delve into critical topics, including the biomarkers indicative of aging and the factors that accelerate this process. Throughout the symposium, each expert presented their research findings and offered profound insights into the mechanisms, biomarkers, and potential interventions for combating aging. Here, several of the editorial board members at the symposium answer the questions posed by Life Medicine.

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Haim Y. Cohen, Vera Gorbunova, Steve Horvath, Brian K. Kennedy, Wei Li, João Pedro de Magalhães, Andrei Seluanov, Moshi Song, Keiichiro Suzuki. Perspectives on the essence and drivers of aging. Life Medicine, 2025, 4(2): lnaf006 DOI:10.1093/lifemedi/lnaf006