Establishment of novel colorectal cancer organoid model based on tumor microenvironment analysis

Zhidong Xu; Shengwen Meng; Ran Xu; De Ma; Emmanuel Enoch Dzakah; Hailun Zheng; Tingjing Yao; Chao Ni; Bing Zhao

doi:10.1093/lifemedi/lnae027

Life Medicine ›› 2024, Vol. 3 ›› Issue (4) : lnae027 DOI: 10.1093/lifemedi/lnae027

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Establishment of novel colorectal cancer organoid model based on tumor microenvironment analysis

Zhidong Xu ¹^,²^,³
, Shengwen Meng ¹^,²^,³
, Ran Xu ²
, De Ma ⁴
, Emmanuel Enoch Dzakah ⁴
, Hailun Zheng ³
, Tingjing Yao ³
, Chao Ni ⁴^,^†
, Bing Zhao ¹^,²^,⁴^,⁵^,^†

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Zhidong Xu, Shengwen Meng, Ran Xu, De Ma, Emmanuel Enoch Dzakah, Hailun Zheng, Tingjing Yao, Chao Ni, Bing Zhao. Establishment of novel colorectal cancer organoid model based on tumor microenvironment analysis. Life Medicine, 2024, 3(4): lnae027 DOI:10.1093/lifemedi/lnae027

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References

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[1]	van de Wetering M , Francies HE , Francis JM , et al. Prospective derivation of a living organoid biobank of colorectal cancer patients. Cell 2015; 161: 933- 45.

[2]	Yao Y , Xu X , Yang L , et al. Patient-derived organoids predict chemoradiation responses of locally advanced rectal cancer. Cell Stem Cell 2020; 26: 17- 26.e6.

[3]	Zhang S , Xu G , Wu J , et al. Microphysiological constructs and systems: biofabrication tactics, biomimetic evaluation approaches, and biomedical applications. Small Methods 2024; 8: e2300685.

[4]	Sato T , Stange DE , Ferrante M , et al. Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett’s epithelium. Gastroenterology 2011; 141: 1762- 72.

[5]	Dijkstra KK , Monkhorst K , Schipper LJ , et al. Challenges in establishing pure lung cancer organoids limit their utility for personalized medicine. Cell Rep 2020; 31: 107588.

[6]	Lee HO , Hong Y , Etlioglu HE , et al. Lineage-dependent gene expression programs infuence the immune landscape of colorectal cancer. Nat Genet 2020; 52: 594- 603.

[7]	Cheng C , Wang J , Xu P , et al. Gremlin1 is a therapeutically targetable FGFR1 ligand that regulates lineage plasticity and castration resistance in prostate cancer. Nat Cancer 2022; 3: 565- 80.

[8]	Johnson DE , O’Keefe RA , Grandis JR . Targeting the IL-6/JAK/STAT3 signalling axis in cancer. Nat Rev Clin Oncol 2018; 15: 234- 48.

[9]	Sato T , Vries RG , Snippert HJ , et al. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 2009; 459: 262- 5.