Unlocking heart anti-aging potential: the SIRT2-STAT3-CDKN2B pathway as a bridge between fiction and reality

Chunyu Chen , Jingxuan Liu , Wei Yu

Life Medicine ›› 2024, Vol. 3 ›› Issue (3) : lnae020

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Life Medicine ›› 2024, Vol. 3 ›› Issue (3) : lnae020 DOI: 10.1093/lifemedi/lnae020
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Unlocking heart anti-aging potential: the SIRT2-STAT3-CDKN2B pathway as a bridge between fiction and reality

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Chunyu Chen, Jingxuan Liu, Wei Yu. Unlocking heart anti-aging potential: the SIRT2-STAT3-CDKN2B pathway as a bridge between fiction and reality. Life Medicine, 2024, 3(3): lnae020 DOI:10.1093/lifemedi/lnae020

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References

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Winnik S , Auwerx J , Sinclair DA , et al. Protective effects of sirtuins in cardiovascular diseases: from bench to bedside. Eur Heart J 2015; 36: 3404- 12.

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Tang X , Chen XF , Wang NY , et al. SIRT2 acts as a cardioprotective deacetylase in pathological cardiac hypertrophy. Circulation 2017; 136: 2051- 67.

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Zhang Y , Wang X , Li XK , et al. Sirtuin 2 deficiency aggravates ageing-induced vascular remodelling in humans and mice. Eur Heart J 2023; 44: 2746- 59.

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Zhao Y , Xie L , Shen C , et al. SIRT2-knockdown rescues GARS-induced Charcot-Marie-Tooth neuropathy. Aging Cell 2021; 20: e13391.

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Ye Y , Yang K , Liu H , et al. SIRT2 counteracts primate cardiac aging via deacetylation of STAT3 that silences CDKN2B. Nat Aging 2023; 3: 1269- 87.

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