Truncated DAZL mutation reduces NANOS3 expression in primordial germ cells and leads to premature ovarian insufficiency

Qingyuan Liu , Ting Guo , An Yan , Kehkooi Kee

Life Medicine ›› 2024, Vol. 3 ›› Issue (2) : lnae007

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Life Medicine ›› 2024, Vol. 3 ›› Issue (2) : lnae007 DOI: 10.1093/lifemedi/lnae007
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Truncated DAZL mutation reduces NANOS3 expression in primordial germ cells and leads to premature ovarian insufficiency

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Qingyuan Liu, Ting Guo, An Yan, Kehkooi Kee. Truncated DAZL mutation reduces NANOS3 expression in primordial germ cells and leads to premature ovarian insufficiency. Life Medicine, 2024, 3(2): lnae007 DOI:10.1093/lifemedi/lnae007

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Ke H , Tang S , Guo T , et al. Landscape of pathogenic mutations in premature ovarian insufficiency. Nat Med. 2023; 29: 483- 492.

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Yan A , Xiong J , Zhu J , et al. DAZL regulates proliferation of human primordial germ cells by direct binding to precursor miRNAs and enhances DICER processing activity. Nucleic Acids Res 2022; 50: 11255- 72.

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Yang CR , Rajkovic G , Daldello EM , et al. The RNA-binding protein DAZL functions as repressor and activator of mRNA translation during oocyte maturation. Nat Commun 2020; 11: 1399.

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Brook M , Smith JW , Gray NK . The DAZL and PABP families: RNA-binding proteins with interrelated roles in translational control in oocytes. Reproduction 2009; 137: 595- 617.

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Suzuki H , Tsuda M , Kiso M , et al. Nanos3 maintains the germ cell lineage in the mouse by suppressing both Bax-dependent and -independent apoptotic pathways. Dev Biol 2008; 318: 133- 42.

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The Author(s) 2024. Published by Oxford University Press on behalf of Higher Education Press.

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