Programmable G-to-Y base editing using engineered DNA glycosylase

Huawei Tong; Tong Li; Hui Yang

doi:10.1093/lifemedi/lnae005

Life Medicine ›› 2024, Vol. 3 ›› Issue (1) : lnae005 DOI: 10.1093/lifemedi/lnae005

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Programmable G-to-Y base editing using engineered DNA glycosylase

Huawei Tong ¹
, Tong Li ¹
, Hui Yang ¹^,²^,^†

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Huawei Tong, Tong Li, Hui Yang. Programmable G-to-Y base editing using engineered DNA glycosylase. Life Medicine, 2024, 3(1): lnae005 DOI:10.1093/lifemedi/lnae005

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References

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[1]	Gaudelli NM, Komor AC, Rees HA, et al. Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage. Nature 2017;551:464–71.

[2]	Komor AC, Kim YB, Packer MS, et al. Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage. Nature 2016;533:420–4.

[3]	Kurt IC, Zhou R, Iyer S, et al. CRISPR C-to-G base editors for inducing targeted DNA transversions in human cells. Nat Biotechnol 2021;39:41–6.

[4]	Zhao D, Li J, Li S, et al. Glycosylase base editors enable C-to-A and C-to-G base changes. Nat Biotechnol 2021;39:35–40.

[5]	Tong H, Wang X, Liu Y, et al. Programmable A-to-Y base editing by fusing an adenine base editor with an N-methylpurine DNA glycosylase. Nat Biotechnol 2023;41:1080–4.