Transglutaminase-crosslinked extracellular matrix in cirrhotic liver tissues provides pro-fibrotic mechano-microenvironment for cells

Cheng Lyu , Wenyu Kong , Yan Zhang , Zhiqiang Liu , Kaini Liang , Yanan Du

Life Medicine ›› 2023, Vol. 2 ›› Issue (6) : 8

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Life Medicine ›› 2023, Vol. 2 ›› Issue (6) : 8 DOI: 10.1093/lifemedi/lnad030
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Transglutaminase-crosslinked extracellular matrix in cirrhotic liver tissues provides pro-fibrotic mechano-microenvironment for cells

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Cheng Lyu, Wenyu Kong, Yan Zhang, Zhiqiang Liu, Kaini Liang, Yanan Du. Transglutaminase-crosslinked extracellular matrix in cirrhotic liver tissues provides pro-fibrotic mechano-microenvironment for cells. Life Medicine, 2023, 2(6): 8 DOI:10.1093/lifemedi/lnad030

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Pellicoro A, Ramachandran P, Iredale JP, et al. Liver fibrosis and repair: immune regulation of wound healing in a solid organ. Nat Rev Immunol 2014;14:181–94.

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Kong W, Lyu C, Liao H, et al. Collagen crosslinking: effect on structure, mechanics and fibrosis progression. Biomed Mater 2021;16:6.

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Lyu C, Kong W, Liu Z, et al. Advanced glycation end-products as mediators of the aberrant crosslinking of extracellular matrix in scarred liver tissue. Nat Biomed Eng 2023. doi:10.1038/ s41551-023-01019-z.

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The Author(s) 2023. Published by Oxford University Press on behalf of Higher Education Press.

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