Novel single-cell mtDNA sequencing technology reveals hidden mutations in oocytes, blastoids, and stem cells

Ismail M. Shakir; Mo Li

doi:10.1093/lifemedi/lnad028

Life Medicine ›› 2023, Vol. 2 ›› Issue (4) : 1 DOI: 10.1093/lifemedi/lnad028

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Novel single-cell mtDNA sequencing technology reveals hidden mutations in oocytes, blastoids, and stem cells

Ismail M. Shakir ¹
, Mo Li ¹^,²^,^†

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Ismail M. Shakir, Mo Li. Novel single-cell mtDNA sequencing technology reveals hidden mutations in oocytes, blastoids, and stem cells. Life Medicine, 2023, 2(4): 1 DOI:10.1093/lifemedi/lnad028

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References

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[1]	Bi C, Wang L, Fan Y, et al. Single-cell individual full-length mtDNA sequencing by iMiGseq uncovers unexpected heteroplasmy shifts in mtDNA editing. Nucleic Acids Res 2023;51:e48.

[2]	Bi C, Wang L, Fan Y, et al. Quantitative haplotype-resolved analysis of mitochondrial DNA heteroplasmy in human single oocytes, blastoids, and pluripotent stem cells. Nucleic Acids Res 2023;51:3793–805.

[3]	Bi C, Wang L, Yuan B, et al. Long-read individual-molecule sequencing reveals CRISPR-induced genetic heterogeneity in human ESCs. Genome Biol 2020;21:213.

[4]	Fan Y, Min Z, Alsolami S, et al. Generation of human blastocyst-like structures from pluripotent stem cells. Cell Discov 2021;7:81.

[5]	Mok BY, de Moraes MH, Zeng J, et al. A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing. Nature 2020;583:631–7.