Bone morphogenetic protein 7 derived from DPP4+ cells in beige fat ameliorates age-associated metabolic dysfunction

Mingwei Guo , Jun Zhang , Ying Ma , Xia Wu , Jing Yao , Dongmei Wang , Jin Qiu , Peng Lu , Banru Chen , Jiqiu Wang , Lingyan Xu , Xinran Ma

Life Medicine ›› 2023, Vol. 2 ›› Issue (4) : 8

PDF (2274KB)
Life Medicine ›› 2023, Vol. 2 ›› Issue (4) : 8 DOI: 10.1093/lifemedi/lnad025
Letter

Bone morphogenetic protein 7 derived from DPP4+ cells in beige fat ameliorates age-associated metabolic dysfunction

Author information +
History +
PDF (2274KB)

Cite this article

Download citation ▾
Mingwei Guo, Jun Zhang, Ying Ma, Xia Wu, Jing Yao, Dongmei Wang, Jin Qiu, Peng Lu, Banru Chen, Jiqiu Wang, Lingyan Xu, Xinran Ma. Bone morphogenetic protein 7 derived from DPP4+ cells in beige fat ameliorates age-associated metabolic dysfunction. Life Medicine, 2023, 2(4): 8 DOI:10.1093/lifemedi/lnad025

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

Bartelt A, Heeren J. Adipose tissue browning and metabolic health. Nat Rev Endocrinol 2014;10:24–36.

[2]

Salazar VS, Gamer LW, Rosen V. BMP signalling in skeletal development, disease and repair. Nat Rev Endocrinol 2016;12:203–21.

[3]

Tseng YH, Kokkotou E, Schulz TJ, et al. New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature 2008;454:1000–4.

[4]

McDonald ME, Li C, Bian H, et al. Myocardin-related transcription factor A regulates conversion of progenitors to beige adipocytes. Cell 2015;160:105–18.

[5]

Maniyadath B, Zhang Q, Gupta RK, et al. Adipose tissue at single-cell resolution. Cell Metab 2023;35:386–413.

[6]

Neely MD, Litt MJ, Tidball AM, et al. DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction. ACS Chem Neurosci 2012;3:482–91.

[7]

Desmaris E, Keruzore M, Saulnier A, et al. DMRT5, DMRT3, and EMX2 cooperatively repress Gsx2 at the pallium-subpallium boundary to maintain cortical identity in dorsal telencephalic progenitors. J Neurosci 2018;38:9105–21.

[8]

Weiskirchen R, Meurer SK. BMP-7 counteracting TGF-beta1 activities in organ fibrosis. Front Biosci 2013;18:1407–34.

[9]

Qian SW, Tang Y, Li X, et al. BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis. Proc Natl Acad Sci U S A 2013;110:E798–807.

[10]

Shan B, Shao M, Zhang Q, et al. Cold-responsive adipocyte progenitors couple adrenergic signaling to immune cell activation to promote beige adipocyte accrual. Genes Dev 2021;35:1333–8.

RIGHTS & PERMISSIONS

The Author(s) 2023. Published by Oxford University Press on behalf of Higher Education Press.

AI Summary AI Mindmap
PDF (2274KB)

Supplementary files

MDC-0008-23025-XM_suppl_1

467

Accesses

0

Citation

Detail

Sections
Recommended

AI思维导图

/