Mosaic somatic HRAS mutation causes unilateral psoriasis

Rina Su , Huanwei Huang , Ying Chang , Yi Yu , Jun Cui , Ting Chen , Bin Li , Wenhui Wang

Life Medicine ›› 2023, Vol. 2 ›› Issue (3) : 10

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Life Medicine ›› 2023, Vol. 2 ›› Issue (3) : 10 DOI: 10.1093/lifemedi/lnad018
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Mosaic somatic HRAS mutation causes unilateral psoriasis

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Rina Su, Huanwei Huang, Ying Chang, Yi Yu, Jun Cui, Ting Chen, Bin Li, Wenhui Wang. Mosaic somatic HRAS mutation causes unilateral psoriasis. Life Medicine, 2023, 2(3): 10 DOI:10.1093/lifemedi/lnad018

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Griffiths CEM, Armstrong AW, Gudjonsson JE, et al. Psoriasis. Lancet 2021;397:1301–15.

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Lin P, Baldassare JJ, Voorhees JJ, et al. Increased activation of Ras in psoriatic lesions. Skin Pharmacol Appl Skin Physiol 1999;12:90–7.

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Yu Z, Gong Y, Cui L, et al. High-throughput transcriptome and pathogenesis analysis of clinical psoriasis. J Dermatol Sci 2020;98:109–18.

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Denayer E, Parret A, Chmara M, et al. Mutation analysis in Costello syndrome: functional and structural characterization of the HRAS p.Lys117Arg mutation. Hum Mutat 2008;29:232–9.

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Groesser L, Herschberger E, Ruetten A, et al. Postzygotic HRAS and KRAS mutations cause nevus sebaceous and Schimmelpenning syndrome. Nat Genet 2012;44:783–7.

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Hafner C, Toll A, Gantner S, et al. Keratinocytic epidermal nevi are associated with mosaic RAS mutations. J Med Genet 2012;49:249–53.

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Gunderson AJ, Mohammed J, Horvath FJ, et al. CD8(+) T cells mediate RAS-induced psoriasis-like skin inflammation through IFN-γ. J Invest Dermatol 2013;133:955–63.

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Tarutani M, Imai Y, Yasuda K, et al. Neutrophil-dominant psoriasis-like skin inflammation induced by epidermal-specific expression of Raf in mice. J Dermatol Sci 2010;58:28–35.

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The Author(s) 2023. Published by Oxford University Press on behalf of Higher Education Press.

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