A framework of biomarkers for brain aging: a consensus statement by the Aging Biomarker Consortium

Aging Biomarker Consortium,Yu-Juan Jia; Jun Wang; Jun-Rong Ren; Piu Chan; Shengdi Chen; Xiao-Chun Chen; Jagadish K Chhetri; Junhong Guo; Qihao Guo; Lingjing Jin; Qiang Liu; Qiang Liu; Wenlin Ma; Zhiyong Mao; Moshi Song; Weihong Song; Yi Tang; Difei Wang; Peijun Wang; Lize Xiong; Keqiang Ye; Junjian Zhang; Weiqi Zhang; Xiaoqing Zhang; Yunwu Zhang; Zhanjun Zhang; Zhuohua Zhang; Jialin Zheng; Guang-Hui Liu; Yi Eve Sun; Yan-Jiang Wang; Gang Pei

doi:10.1093/lifemedi/lnad017

Life Medicine ›› 2023, Vol. 2 ›› Issue (3) : 5 DOI: 10.1093/lifemedi/lnad017

Forum

A framework of biomarkers for brain aging: a consensus statement by the Aging Biomarker Consortium

Aging Biomarker Consortium,Yu-Juan Jia ¹^,²
, Jun Wang ¹
, Jun-Rong Ren ¹
, Piu Chan ³^,^†
, Shengdi Chen ⁴^,^†
, Xiao-Chun Chen ⁵^,^†
, Jagadish K Chhetri ⁶^,^†
, Junhong Guo ⁷^,^†
, Qihao Guo ⁸^,^†
, Lingjing Jin ⁹^,^†
, Qiang Liu ¹⁰^,^†
, Qiang Liu ¹¹^,^†
, Wenlin Ma ¹²^,^†
, Zhiyong Mao ¹³^,^†
, Moshi Song ¹⁴^,^†
, Weihong Song ¹⁵^,^†
, Yi Tang ¹⁶^,^†
, Difei Wang ¹⁷^,^†
, Peijun Wang ¹⁸^,^†
, Lize Xiong ¹⁹^,^†
, Keqiang Ye ²⁰^,^†
, Junjian Zhang ²¹^,^†
, Weiqi Zhang ²²^,^†
, Xiaoqing Zhang ²³^,^†
, Yunwu Zhang ²⁴^,^†
, Zhanjun Zhang ²⁵^,^†
, Zhuohua Zhang ²⁶^,^†
, Jialin Zheng ²⁷^,^†
, Guang-Hui Liu ²⁸^,²⁹^,³⁰^,^†
, Yi Eve Sun ³¹^,^†
, Yan-Jiang Wang ³²^,³³^,^†
, Gang Pei ³⁴^,^†

Author information +

¹. Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing 400042, China

². Department of Neurology, First Affiliated Hospital, Shanxi Medical University, Taiyuan 030001, China

³. National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing 100053, China

⁴. Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

⁵. Department of Neurology, Union Hospital of Fujian Medical University, Fuzhou 350001, China

⁶. National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing 100053, China

⁷. Department of Neurology, First Affiliated Hospital, Shanxi Medical University, Taiyuan 030001, China

⁸. Department of Gerontology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China

⁹. Department of Neurology and Neurological Rehabilitation, Shanghai Disabled Persons’ Federation Key Laboratory of Intelligent Rehabilitation Assistive Devices and Technologies, Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), Tongji University, School of Medicine, Shanghai 200092, China

¹⁰. Institute on Aging and Brain Disorders, The First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China

¹¹. Department of Neurology, Institute of Neuroimmunology, Tianjin Medical University General Hospital, Tianjin 300052, China

¹². Department of Cardiology, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai 200092, China

¹³. Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China

¹⁴. State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

¹⁵. Institute of Aging, Key Laboratory of Alzheimer’s Disease of Zhejiang Province, Zhejiang Clinical Research Center for Mental Disorders, School of Mental Health and The Affiliated Kangning Hospital, Wenzhou Medical University, Oujiang Laboratory, Wenzhou, Zhejiang 325035, China

¹⁶. Department of Neurology & Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders, Beijing 100053, China

¹⁷. Department of Gerontology, Shengjing Hospital of China Medical University, Shenyang 110000, China

¹⁸. Department of Radiology, Tongji Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, The Institute for Biomedical Engineering & Nano Science, School of Medicine, Tongji University, Shanghai 200092, China

¹⁹. Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital, Tongji University, Shanghai 200434, China

²⁰. Faculty of Life and Health Sciences, Shenzhen Institute of Advanced Technology, Chinese Academy of Science, Shenzhen 518055, China

²¹. Department of Neurology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China

²². CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China

²³. Translational Medical Center for Stem Cell Therapy, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China

²⁴. Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen 361102, China

²⁵. State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China

²⁶. Hunan Key Laboratory of Molecular Precision Medicine, Department of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha 410008, China

²⁷. Center for Translational Neurodegeneration and Regenerative Therapy, Tongji Hospital affiliated to Tongji University School of Medicine, Shanghai 200072, China

²⁸. University of Chinese Academy of Sciences, Beijing 100049, China

²⁹. State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

³⁰. Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China

³¹. Stem Cell Translational Research Center, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China

³². Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing 400042, China

³³. Key Laboratory of Ageing and Brain Disease, Chongqing 400042, China

³⁴. Collaborative Innovation Center for Brain Science, School of Life Science and Technology, Tongji University, Shanghai 200092, China

pbchan@hotmail.com

chensd@rjh.com.cn

chenxc998@163.com

chhetri_jk@hotmail.com

neuroguo@163.com

qhguo@sjtu.edu.cn

lingjingjin@tongji.edu.cn

liuq2012@ustc.edu.cn

qliu@tmu.edu.cn

mawenlin@tongji.edu.cn

zhiyong_mao@tongji.edu.cn

songmoshi@ioz.ac.cn

weihong@mail.ubc.ca

tangyi@xwhosp.org

dfwang@cmu.edu.cn

pjwang002547@163.com

makxlz@126.com

kq.ye@siat.ac.cn

wdsjkx@163.com

zhangwq@big.ac.cn

xqzhang@tongji.edu.cn

Yunzhang@xmu.edu.cn

zhang_rzs@bnu.edu.cn

zhangzhuohua@sklmg.edu.cn

Jialinzheng@tongji.edu.cn

ghliu@ioz.ac.cn.

yi.eve.sun@gmail.com

yanjiang_wang@tmmu.edu.cn

peigang@tongji.edu.cn

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Abstract

China and the world are facing severe population aging and an increasing burden of age-related diseases. Aging of the brain causes major age-related brain diseases, such as neurodegenerative diseases and stroke. Identifying biomarkers for the effective assessment of brain aging and establishing a brain aging assessment system could facilitate the development of brain aging intervention strategies and the effective prevention and treatment of aging-related brain diseases. Thus, experts from the Aging Biomarker Consortium (ABC) have combined the latest research results and practical experience to recommend brain aging biomarkers and form an expert consensus, aiming to provide a basis for assessing the degree of brain aging and conducting brain-aging-related research with the ultimate goal of improving the brain health of elderly individuals in both China and the world.

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Aging Biomarker Consortium,Yu-Juan Jia, Jun Wang, Jun-Rong Ren, Piu Chan, Shengdi Chen, Xiao-Chun Chen, Jagadish K Chhetri, Junhong Guo, Qihao Guo, Lingjing Jin, Qiang Liu, Qiang Liu, Wenlin Ma, Zhiyong Mao, Moshi Song, Weihong Song, Yi Tang, Difei Wang, Peijun Wang, Lize Xiong, Keqiang Ye, Junjian Zhang, Weiqi Zhang, Xiaoqing Zhang, Yunwu Zhang, Zhanjun Zhang, Zhuohua Zhang, Jialin Zheng, Guang-Hui Liu, Yi Eve Sun, Yan-Jiang Wang, Gang Pei. A framework of biomarkers for brain aging: a consensus statement by the Aging Biomarker Consortium. Life Medicine, 2023, 2(3): 5 DOI:10.1093/lifemedi/lnad017

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