The 3D genome and its impacts on human health and disease

Siqi Wang, Zhengyu Luo, Weiguang Liu, Tengfei Hu, Zhongying Zhao, Michael G. Rosenfeld, Xiaoyuan Song

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Life Medicine ›› 2023, Vol. 2 ›› Issue (2) : 6. DOI: 10.1093/lifemedi/lnad012
Review

The 3D genome and its impacts on human health and disease

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Abstract

Eukaryotic genomes are highly compacted in the cell nucleus. Two loci separated by a long linear distance can be brought into proximity in space through DNA-binding proteins and RNAs, which contributes profoundly to the regulation of gene expression. Recent technology advances have enabled the development and application of the chromosome conformation capture (3C) technique and a host of 3C-based methods that enable genome-scale investigations into changes in chromatin high-order structures during diverse physiological processes and diseases. In this review, we introduce 3C-based technologies and discuss how they can be utilized to glean insights into the impacts of three-dimensional (3D) genome organization in normal physiological and disease processes.

Keywords

3D genome / 3C and 3C-based method / 3D genome changes in health and diseases

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Siqi Wang, Zhengyu Luo, Weiguang Liu, Tengfei Hu, Zhongying Zhao, Michael G. Rosenfeld, Xiaoyuan Song. The 3D genome and its impacts on human health and disease. Life Medicine, 2023, 2(2): 6 https://doi.org/10.1093/lifemedi/lnad012

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