Elucidating the dynamics of polypeptide hormones in the physiological and preeclampsic placental trophoblast cells across gestation at single-cell level

Hao Wu; Chenxiang Luo; Yin Rong; Ruoxuan Yu; Yan Zhao; Long Yan; Hongmei Wang

doi:10.1093/lifemedi/lnad003

Life Medicine ›› 2023, Vol. 2 ›› Issue (3) : 8 DOI: 10.1093/lifemedi/lnad003

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Elucidating the dynamics of polypeptide hormones in the physiological and preeclampsic placental trophoblast cells across gestation at single-cell level

Hao Wu ¹^,³^,⁴
, Chenxiang Luo ²
, Yin Rong ¹^,³^,⁴^,⁵
, Ruoxuan Yu ¹^,³^,⁴^,⁵
, Yan Zhao ¹^,³^,⁴^,⁵
, Long Yan ¹^,³^,⁴^,^†
, Hongmei Wang ¹^,³^,⁴^,⁵^,^†

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Hao Wu, Chenxiang Luo, Yin Rong, Ruoxuan Yu, Yan Zhao, Long Yan, Hongmei Wang. Elucidating the dynamics of polypeptide hormones in the physiological and preeclampsic placental trophoblast cells across gestation at single-cell level. Life Medicine, 2023, 2(3): 8 DOI:10.1093/lifemedi/lnad003

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References

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[1]	Vento-Tormo R, Efremova M, Botting RA, et al. Single-cell reconstruction of the early maternal-fetal interface in humans. Nature 2018;563:347–53.

[2]	Liu Y., Fan X., Wang R, et al. Single-cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placenta. Cell Res 2018;28:819–32.

[3]	Hu KL, Chang HM, Zhao HC, et al. Potential roles for the kisspeptin/kisspeptin receptor system in implantation and placentation. Hum Reprod Update 2019;25:326–43.

[4]	Okae H, Toh H, Sato T, et al. Derivation of human trophoblast stem cells. Cell Stem Cell 2018;22:50–63. e6.

[5]	Wang Y, Wu H, Jiang X, et al. LMNA determines nuclear morphology during syncytialization of human trophoblast stem cells. Front Cell Dev Biol 2022;10:836390.

[6]	Chappell LC, Cluver CA, Kingdom J, et al. Pre-eclampsia. Lancet 2021;398:341–54.

[7]	Zhou W, Wang H, Yang Y, et al. Trophoblast cell subtypes and dysfunction in the placenta of individuals with preeclampsia revealed by single-cell RNA sequencing. Mol Cells 2022;45:317–28.