
Functional integration of Cas9 gene into the genome of rhesus monkey: possibility of a new biomedical model?
Yi Wang, Junmo Wu, Xuan Wang, Yu Kang, Chu Chu, Yuqiang Zeng, Zhenzhen Chen, Ziyi Zhao, Xinglong Chen, Baohong Tian, Yuyu Niu
Life Medicine ›› 2023, Vol. 2 ›› Issue (1) : 12.
Functional integration of Cas9 gene into the genome of rhesus monkey: possibility of a new biomedical model?
[1] |
Huang Y, Ding CH, Liang PP, et al. HBB-deficient Macaca fascicularis monkey presents with human β-thalassemia. Protein Cell 2019;10:538–42.
CrossRef
Google scholar
|
[2] |
Niu Y, Yu Y, Bernat A, et al. Transgenic rhesus monkeys produced by gene transfer into early-cleavage-stage embryos using a simian immunodeficiency virus-based vector. Proc Natl Acad Sci U S A 2010;107:17663–7.
CrossRef
Google scholar
|
[3] |
Wolf G, Macfarlan TS. Revealing the complexity of retroviral repression. Cell 2015;163:30–2.
CrossRef
Google scholar
|
[4] |
Elsasser SJ, Noh K-M, Diaz N, et al. Histone H3.3 is required for endogenous retroviral element silencing in embryonic stem cells. Nature 2015;522:240–4.
CrossRef
Google scholar
|
[5] |
Zhu Y, Wang GZ, Cingöz O, et al. NP220 mediates silencing of unintegrated retroviral DNA. Nature 2018;564:278–82.
CrossRef
Google scholar
|
[6] |
Ellis J. Silencing and variegation of gammaretrovirus and lentivirus vectors. Hum Gene Ther 2005;16:1241–6.
CrossRef
Google scholar
|
[7] |
Persons DA, Hargrove PW, Allay ER, et al. The degree of phenotypic correction of murine beta -thalassemia intermedia following lentiviral- mediated transfer of a human gamma-globin gene is influenced by chromosomal position effects and vector copy number. Blood 2003;101:2175–83.
CrossRef
Google scholar
|
[8] |
Pannell D, Osborne CS, Yao S, et al. Retrovirus vector silencing is de novo methylase independent and marked by a repressive histone code. EMBO J 2000;19:5884–94.
CrossRef
Google scholar
|
[9] |
Wang K, Jin Q, Ruan D, et al. Cre-dependent Cas9-expressing pigs enable efficient in vivo genome editing. Genome Res 2017;27:2061–71.
CrossRef
Google scholar
|
[10] |
Charlesworth CT, Deshpande PS, Dever DP, et al. Identification of preexisting adaptive immunity to Cas9 proteins in humans. Nat Med 2019;25:249–54.
CrossRef
Google scholar
|
/
〈 |
|
〉 |