iMAPping the Perturb-Atlas

Yiwen Sun , Wenyang Lin , Ravinder Kaundal , Tian Chi

Life Medicine ›› 2023, Vol. 2 ›› Issue (1) : 5

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Life Medicine ›› 2023, Vol. 2 ›› Issue (1) : 5 DOI: 10.1093/lifemedi/lnac057
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iMAPping the Perturb-Atlas

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Yiwen Sun, Wenyang Lin, Ravinder Kaundal, Tian Chi. iMAPping the Perturb-Atlas. Life Medicine, 2023, 2(1): 5 DOI:10.1093/lifemedi/lnac057

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References

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Rood JE, Regev A. The legacy of the Human Genome Project. Science 2021;373:1442–3.

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Liu B, Jing Z, Zhang X, et al. Large-scale multiplexed mosaic CRISPR perturbation in the whole organism. Cell 2022;185:3008–24.e16.

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Boone C, Andrews BJ. The Indispensable Genome. Science 2015;350:1028–29.

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Replogle JM, Norman TM, Xu A, et al. Combinatorial single-cell CRISPR screens by direct guide RNA capture and targeted sequencing. Nat Biotechnol 2020;38:954–61.

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Kampmann M. CRISPRi and CRISPRa screens in mammalian cells for precision biology and medicine. ACS Chem Biol 2018;13:406–16.

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Tong H, Huang J, Xiao Q, et al. High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects. Nat Biotechnol 2022;1–12.

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