Biallelic mutations in <i>IQCN</i>, encoding a novel acroplaxome protein, lead to fertilization failure and male infertility with defects in the acrosome and shaping of the spermatid head in humans and mice

Yanwei Sha; Yongjie Chen; Xiong Wang; Ranran Meng; Xiaoyan Yang; Youzhu Li; Pengpeng Jin; Shanze Li; Jie Chen; Tianyu WShao; Dan Xu; Yibiao Guo; Zhaodi Jiang; Yuhua Li; Shuntai Yu; Lin Li; Fengchao Wang

doi:10.1093/lifemedi/lnac050

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Life Medicine ›› 2023, Vol. 2 ›› Issue (2) : 11. DOI: 10.1093/lifemedi/lnac050

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Biallelic mutations in IQCN, encoding a novel acroplaxome protein, lead to fertilization failure and male infertility with defects in the acrosome and shaping of the spermatid head in humans and mice

Yanwei Sha¹^,²^,³ ,
Yongjie Chen⁴ ,
Xiong Wang⁵ ,
Ranran Meng⁶^,⁷ ,
Xiaoyan Yang⁷ ,
Youzhu Li⁸ ,
Pengpeng Jin⁷ ,
Shanze Li⁶^,⁷ ,
Jie Chen⁵ ,
Tianyu WShao⁷^,⁹ ,
Dan Xu⁷ ,
Yibiao Guo¹⁰ ,
Zhaodi Jiang⁷ ,
Yuhua Li⁷ ,
Shuntai Yu⁷^,⁹ ,
Lin Li⁴ ,
Fengchao Wang⁷^,¹¹

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Yanwei Sha, Yongjie Chen, Xiong Wang, Ranran Meng, Xiaoyan Yang, Youzhu Li, Pengpeng Jin, Shanze Li, Jie Chen, Tianyu WShao, Dan Xu, Yibiao Guo, Zhaodi Jiang, Yuhua Li, Shuntai Yu, Lin Li, Fengchao Wang. Biallelic mutations in IQCN, encoding a novel acroplaxome protein, lead to fertilization failure and male infertility with defects in the acrosome and shaping of the spermatid head in humans and mice. Life Medicine, 2023, 2(2): 11 https://doi.org/10.1093/lifemedi/lnac050

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