NAD<sup>+</sup> is critical for maintaining acetyl-CoA and H3K27ac in embryonic stem cells by Sirt1-dependent deacetylation of AceCS1

Yi Wu; Yang Liu; Zhihong Hao; Xingguo Liu

doi:10.1093/lifemedi/lnac046

PDF(384 KB)

Life Medicine ›› 2022, Vol. 1 ›› Issue (3) : 401-405. DOI: 10.1093/lifemedi/lnac046

Letter

NAD⁺ is critical for maintaining acetyl-CoA and H3K27ac in embryonic stem cells by Sirt1-dependent deacetylation of AceCS1

Yi Wu¹^,² ,
Yang Liu¹^,²^,³ ,
Zhihong Hao¹^,²^,³ ,
Xingguo Liu¹^,²^,⁴

Author information +

History +

Cite this article

EndNote

Ris (Procite)

Bibtex

Download citation ▾

Yi Wu, Yang Liu, Zhihong Hao, Xingguo Liu. NAD⁺ is critical for maintaining acetyl-CoA and H3K27ac in embryonic stem cells by Sirt1-dependent deacetylation of AceCS1. Life Medicine, 2022, 1(3): 401‒405 https://doi.org/10.1093/lifemedi/lnac046

References

Publishing order | Descend order by publishing year | Descend order by cited within

[1]	Ghosh-Choudhary S, Liu J, Finkel T. Metabolic regulation of cell fate and function. Trends Cell Biol 2020;30:201–12. CrossRef Google scholar

[2]	Liu K, Cao J, Shi X, et al. Cellular metabolism and homeostasis in pluripotency regulation. Protein Cell 2020;11:630–40. CrossRef Google scholar

[3]	Wu Y, Chen K, Li L, et al. Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation. Cell Death Differ 2022;29:2316–31. CrossRef Google scholar

[4]	Canto C, Menzies KJ, Auwerx J. NAD(+) metabolism and the control of energy homeostasis: a balancing act between mitochondria and the nucleus. Cell Metab 2015;22:31–53. CrossRef Google scholar

[5]	Lees JG, Gardner DK, Harvey AJ. Nicotinamide adenine dinucleotide induces a bivalent metabolism and maintains pluripotency in human embryonic stem cells. Stem Cells 2020;38:624–38. CrossRef Google scholar

[6]	Moussaieff A, Rouleau M, Kitsberg D, et al. Glycolysis-mediated changes in acetyl-CoA and histone acetylation control the early differentiation of embryonic stem cells. Cell Metab 2015;21:392–402. CrossRef Google scholar

[7]	Hallows WC, Lee S, Denu JM. Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases. Proc Natl Acad Sci USA 2006;103:10230–5. CrossRef Google scholar

[8]	Imai S, Guarente L. NAD+ and sirtuins in aging and disease. Trends Cell Biol 2014;24:464–71. CrossRef Google scholar

[9]	Covarrubias AJ, Perrone R, Grozio A, et al. NAD(+) metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol 2021;22:119–41. CrossRef Google scholar