NAD+ is critical for maintaining acetyl-CoA and H3K27ac in embryonic stem cells by Sirt1-dependent deacetylation of AceCS1

Yi Wu , Yang Liu , Zhihong Hao , Xingguo Liu

Life Medicine ›› 2022, Vol. 1 ›› Issue (3) : 401 -405.

PDF (384KB)
Life Medicine ›› 2022, Vol. 1 ›› Issue (3) : 401 -405. DOI: 10.1093/lifemedi/lnac046
Letter
Letter

NAD+ is critical for maintaining acetyl-CoA and H3K27ac in embryonic stem cells by Sirt1-dependent deacetylation of AceCS1

Author information +
History +
PDF (384KB)

Cite this article

Download citation ▾
Yi Wu, Yang Liu, Zhihong Hao, Xingguo Liu. NAD+ is critical for maintaining acetyl-CoA and H3K27ac in embryonic stem cells by Sirt1-dependent deacetylation of AceCS1. Life Medicine, 2022, 1(3): 401-405 DOI:10.1093/lifemedi/lnac046

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

Ghosh-Choudhary S, Liu J, Finkel T. Metabolic regulation of cell fate and function. Trends Cell Biol 2020;30:201–12.

[2]

Liu K, Cao J, Shi X, et al. Cellular metabolism and homeostasis in pluripotency regulation. Protein Cell 2020;11:630–40.

[3]

Wu Y, Chen K, Li L, et al. Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation. Cell Death Differ 2022;29:2316–31.

[4]

Canto C, Menzies KJ, Auwerx J. NAD(+) metabolism and the control of energy homeostasis: a balancing act between mitochondria and the nucleus. Cell Metab 2015;22:31–53.

[5]

Lees JG, Gardner DK, Harvey AJ. Nicotinamide adenine dinucleotide induces a bivalent metabolism and maintains pluripotency in human embryonic stem cells. Stem Cells 2020;38:624–38.

[6]

Moussaieff A, Rouleau M, Kitsberg D, et al. Glycolysis-mediated changes in acetyl-CoA and histone acetylation control the early differentiation of embryonic stem cells. Cell Metab 2015;21:392–402.

[7]

Hallows WC, Lee S, Denu JM. Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases. Proc Natl Acad Sci USA 2006;103:10230–5.

[8]

Imai S, Guarente L. NAD+ and sirtuins in aging and disease. Trends Cell Biol 2014;24:464–71.

[9]

Covarrubias AJ, Perrone R, Grozio A, et al. NAD(+) metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol 2021;22:119–41.

RIGHTS & PERMISSIONS

The Author(s) 2022. Published by Oxford University Press on behalf of Higher Education Press.

AI Summary AI Mindmap
PDF (384KB)

Supplementary files

lnac046_suppl_supplementary_material

838

Accesses

0

Citation

Detail

Sections
Recommended

AI思维导图

/