Retrotransposon: a versatile player in human preimplantation development and health

Yuliang Qu , Zsuzsanna Izsvák , Jichang Wang

Life Medicine ›› 2023, Vol. 2 ›› Issue (1) : 3

PDF (229KB)
Life Medicine ›› 2023, Vol. 2 ›› Issue (1) : 3 DOI: 10.1093/lifemedi/lnac041
Research Highlight
Research Highlight

Retrotransposon: a versatile player in human preimplantation development and health

Author information +
History +
PDF (229KB)

Cite this article

Download citation ▾
Yuliang Qu, Zsuzsanna Izsvák, Jichang Wang. Retrotransposon: a versatile player in human preimplantation development and health. Life Medicine, 2023, 2(1): 3 DOI:10.1093/lifemedi/lnac041

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

Grow EJ, Flynn RA, Chavez SL, et al. Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells. Nature 2015;522:221–5.

[2]

Yu H, Chen M, Hu Y, et al. Dynamic reprogramming of H3K9me3 at hominoid-specific retrotransposons during human preimplantation development. Cell Stem Cell 2022;29:10311050 e1012–1050.e12.

[3]

Xiang X, Tao Y, DiRusso J, et al. Human reproduction is regulated by retrotransposons derived from ancient Hominidae-specific viral infections. Nat Commun 2022;13:463.

[4]

Xu R, Li S, Wu Q, et al. Stage-specific H3K9me3 occupancy ensures retrotransposon silencing in human pre-implantation embryos. Cell Stem Cell 2022;29:10511066 e1058–1066.e8.

[5]

Padmanabhan Nair V, Liu H, Ciceri G, et al. Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3. Cell Stem Cell 2021;28:1581.e1568.

[6]

Liu X, Liu Z, Sun L, et al. Resurrection of human endogenous retroviruses during aging reinforces senescence. bioRxiv 2021. doi: 10.1101/2021.02.22.432260v1.abstract.

[7]

Liang C, Ke Q, Liu Z, et al. BMAL1 moonlighting as a gatekeeper for LINE1 repression and cellular senescence in primates. Nucleic Acids Res 2022;50:3323–47.

[8]

Marasca F, Sinha S, Vadalà R, et al. LINE1 are spliced in non-canonical transcript variants to regulate T cell quiescence and exhaustion. Nat Genet 2022;54:180–93.

[9]

Rodriguez-Martin B, Alvarez EG, Baez-Ortega A, et al. Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition. Nat Genet 2020;52:306–19.

[10]

Gu Z, Liu Y, Zhang Y, et al. Silencing of LINE-1 retrotransposons is a selective dependency of myeloid leukemia. Nat Genet 2021;53:672–82.

RIGHTS & PERMISSIONS

The Author(s) 2022. Published by Oxford University Press on behalf of Higher Education Press.

AI Summary AI Mindmap
PDF (229KB)

427

Accesses

0

Citation

Detail

Sections
Recommended

AI思维导图

/