YAP/TAZ links mechanosensing to aging

References

[1] López-Otín C, Blasco MA, Partridge L, et al. The hallmarks of aging. Cell 2013;153:1194–217.

[2] Borghesan M, Hoogaars WMH, Varela-Eirin M, et al. A senescence-centric view of aging: implications for longevity and disease. Trends Cell Biol 2020;30:777–91.

[3] Wang C, Jurk D, Maddick M, et al. DNA damage response and cellular senescence in tissues of aging mice. Aging Cell 2009;8:311–23.

[4] Ewald CY. The matrisome during aging and longevity: a systems-level approach toward defining matreotypes promoting healthy aging. Gerontology 2020;66:266–74.

[5] Gudipaty SA, Lindblom J, Loftus PD, et al. Mechanical stretch triggers rapid epithelial cell division through Piezo1. Nature 2017;543:118–21.

[6] Panciera T, Azzolin L, Cordenonsi M, et al. Mechanobiology of YAP and TAZ in physiology and disease. Nat Rev Mol Cell Biol 2017;18:758–70.

[7] Yu, FX, Zhao B, Guan, KL. Hippo pathway in organ size control, tissue homeostasis and cancer. Cell 2015;163:811–28.

[8] Decout A, Katz JD, Venkatraman S, et al. The cGAS-STING pathway as a therapeutic target in inflammatory diseases. Nat Rev Immunol 2021;21:548–69.

[9] Wang S, Xie F, Chu F, et al. YAP antagonizes innate antiviral immunity and is targeted for lysosomal degradation through IKKϵ-mediated phosphorylation. Nat Immunol 2017;18:733–43.

[10] Zhang Q, Meng F, Chen S, et al. Hippo signalling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade. Nat Cell Biol 2017;19:362–74.

RIGHTS & PERMISSIONS

The Author(s) 2022. Published by Oxford University Press on behalf of Higher Education Press.